DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdx and Lztr1

DIOPT Version :9

Sequence 1:	NP_650326.3	Gene:	rdx / 41704	FlyBaseID:	FBgn0264493	Length:	829	Species:	Drosophila melanogaster
Sequence 2:	XP_006248769.1	Gene:	Lztr1 / 360745	RGDID:	1309100	Length:	862	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	110/467 - (23%)
Similarity:	176/467 - (37%)	Gaps:	121/467 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 CNAAANFCDKRLPVNECQASQTARVTSNL-HASSSTMAVSRVP-------SPPLPEVNTPVAENW 477
            ||.....|..::.|...|:.  |::|:|| .........:|:|       |||.|:      ..:
  Rat   226 CNFPVAVCRDKMFVFSGQSG--AKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQ------RRY 282

  Fly   478 CYTQVKVVKFSYMW------TINNFSFCRE---EMGEVLKSSTFS--AGANDKLKWCLRVNPKGL 531
            .:|.|...:..|::      |:.|...|.:   :..||::.|:.|  .||        .|..:..
  Rat   283 GHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGA--------EVPERAS 339

  Fly   532 DEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDF 596
            ..|....|:          ||.|:.||.|                  |.|.|.|:|.....:...
  Rat   340 SSEEASTLT----------SEERSSFKKS------------------RDVFGLDFGTTSTKQPVH 376

  Fly   597 LLDEANGLLPEDKLTIFCEVSVVADSVNI----------SGQSNIVQFK-VPECKLSEDLGNLFD 650
            |..|    ||..:|  |...:|::|::.|          ||:....||. .|:|.|.||.|.|::
  Rat   377 LASE----LPSGRL--FHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWE 435

  Fly   651 NEKFSDVTLSVGGRE--FQAHKAILAARS-----------DVFAAMFEHE--------------M 688
            ..:|.||...:|.:|  .|.|.||:.|||           :..|...|.:              .
  Rat   436 GRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAREWLAQKLEEDGALAPKEAPGSTVGR 500

  Fly   689 EERKLNRVAITDVDHEVLKEMLRFIYTGKAPNLEK-MADDLLAAADKYALE------KLKVMCEE 746
            ....|.||||.:.:....:.:::|:||.|.....| ..:|:|...|.|.|.      :|:.:|.:
  Rat   501 ARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 565

  Fly   747 ALCVNLSVETAAETLILADLHSADQLKAQTIDFI--NTHATDVMETSGWQNMITTHSHLIAEAFR 809
            .:..::.::........|......|||...::||  .:|...|:....::.:   .|.||.|..|
  Rat   566 YIEASVDLQNVLAVCECAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERL---SSPLIVEIVR 627

  Fly   810 ALATQQIPPIGP 821
              ..||.||..|
  Rat   628 --RKQQPPPRTP 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdx	NP_650326.3	MATH_SPOP	483..621	CDD:239743	31/148 (21%)
		BTB	645..749	CDD:279045	33/137 (24%)
		BTB	656..752	CDD:197585	30/129 (23%)
		SPOP_C	752..814	CDD:269807	13/63 (21%)
Lztr1	XP_006248769.1	KELCH repeat	65..111	CDD:276965
		Kelch_3	74..123	CDD:290151
		KELCH repeat	115..169	CDD:276965
		Kelch_3	124..180	CDD:290151
		Kelch_1	171..216	CDD:279660
		Kelch_3	234..289	CDD:290151	14/62 (23%)
		Kelch_1	280..323	CDD:279660	8/42 (19%)
		KELCH repeat	281..323	CDD:276965	8/41 (20%)
		SPOP_C_like	571..631	CDD:269810	13/64 (20%)
		BTB	662..761	CDD:279045
		BTB	665..762	CDD:197585
		SPOP_C_like	765..>800	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910