DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdx and Btbd8

DIOPT Version :9

Sequence 1:	NP_650326.3	Gene:	rdx / 41704	FlyBaseID:	FBgn0264493	Length:	829	Species:	Drosophila melanogaster
Sequence 2:	NP_001365195.1	Gene:	Btbd8 / 100503185	MGIID:	3646208	Length:	1751	Species:	Mus musculus

Alignment Length:	378	Identity:	78/378 - (20%)
Similarity:	138/378 - (36%)	Gaps:	131/378 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 ESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFV--QGKDWGFKKF-IRRD 595
            |:.::.:...::.|.||            |.|..|.:.::..:....:  :|.|..|.:: ...|
Mouse   106 EASEFKAFLQIVYSSNK------------NIKNYEEEIVKKLKVGSLMPEKGPDVSFPRYRTSSD 158

  Fly   596 FLLDEANGLLPEDKLTIFCEVSVVADSVNISGQSNIVQFKV-----PECKLSEDLGNLFDNEKFS 655
            ..|  ..|.:|||                |:|..:....|.     |..:|..||..|:.::.:.
Mouse   159 CFL--GKGEIPED----------------ITGGGDCFISKADSDLEPASELGGDLLKLYLSQHYP 205

  Fly   656 DVTLSVGGREFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDHEVLKEMLRFIYTGKAPN 720
            |:.:.|.||.|:||:|||:|||..||||......|.....:.:..:.|..:..|:.|||.|....
Mouse   206 DIDICVDGRSFRAHRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMNVMMHFIYGGTLDF 270

  Fly   721 LEKM-ADDLLAAADKYALEKLKVM---------CE-------------------------EAL-- 748
            .||. ...:|..||.|.||.|:.:         |.                         |:|
Mouse   271 PEKANVGQILNVADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLIIAHSVGVESLFA 335

  Fly   749 -----------------------------CVNLSVET-----------AAETLIL---------A 764
                                         |:::.:::           .::.||:         |
Mouse   336 DCMNCIISHFARFWSERSFANVPPEIQKTCLSMQIQSLNHGNAAFLLMESDRLIMGLPRVKWTEA 400

  Fly   765 DLHSADQLKAQTIDFINTHATDVMETSGW------QNMITTHSHLIAEAFRAL 811
            .|..|.||:.:.:.||..:.:.::|:..:      |.|.:| :||:.:.|:|:
Mouse   401 ALSMASQLQEECVTFIVENFSQIIESENFTLLLQSQAMSST-AHLLDKIFKAI 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdx	NP_650326.3	MATH_SPOP	483..621	CDD:239743	16/89 (18%)
		BTB	645..749	CDD:279045	38/169 (22%)
		BTB	656..752	CDD:197585	37/161 (23%)
		SPOP_C	752..814	CDD:269807	17/86 (20%)
Btbd8	NP_001365195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..37
		BTB1_POZ_BTBD8	43..146	CDD:349594	7/51 (14%)
		BTB2_POZ_BTBD8	188..308	CDD:349595	38/119 (32%)
		BACK_BTBD8	316..377	CDD:350565	3/60 (5%)
		BACK	<405..436	CDD:350515	6/30 (20%)
		DUF4596	1707..1751	CDD:405945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910