DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc2 and ORC2

DIOPT Version :9

Sequence 1:	NP_731873.1	Gene:	Orc2 / 41703	FlyBaseID:	FBgn0015270	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	XP_011509554.1	Gene:	ORC2 / 4999	HGNCID:	8488	Length:	597	Species:	Homo sapiens

Alignment Length:	597	Identity:	219/597 - (36%)
Similarity:	324/597 - (54%)	Gaps:	75/597 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KESNGKGQEER--IVVNYVEMSDERSSDAEDQEEEESIEESENAARPAAKDLH--LIQSEYNVAG 128
            :|...|.::||  ::||..::..:...|.|  |:::.:.:.:|......:|:.  |........|
Human    29 REGGAKLKKERAQLLVNPKKIIKKPEYDLE--EDDQEVLKDQNYVEIMGRDVQESLKNGSATGGG 91

  Fly   129 TSMFGFNTPKKRDAMALAALNATP--CTP--------------KTPK---------TPRLGVKTP 168
            ..::.|...|..:.||...|...|  .||              |||:         .|.:.:..|
Human    92 NKVYSFQNRKHSEKMAKLDLTFWPFFLTPHQRCASTIYASELAKTPQKSVSFSLKNDPEITINVP 156

  Fly   169 DTKRKKSMD---QPK----------TPAHVRTRVKKQIAKIVADSDEDFSGDESDFRPSDEESSS 220
            .:.:..|..   |||          .|..:|.|:      ||..|..|          |:.|.|:
Human   157 QSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRL------IVPRSHSD----------SESEYSA 205

  Fly   221 SSSSSDAG----NSSDNDAADDEPKTPSRARRAIVVPVLPKTPSAARLRQSARAKKSNEFVPESD 281
            |:|..|.|    :..|.:|.....|..:: .|.:..||..:|||....|.     |:::.|.|
Human   206 SNSEDDEGVAQEHEEDTNAVIFSQKIQAQ-NRVVSAPVGKETPSKRMKRD-----KTSDLVEE-- 262

  Fly   282 GYFHSHASSKILTSDHTLDRLKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWMCI 346
             ||.:|:|||:||||.||.:||..:|....:.:|||::..|...|  :..:.::|...|.|||..
Human   263 -YFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAE--LKQLNQQYEKLFHKWMLQ 324

  Fly   347 LNEGFNILLYGLGSKHQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPANP 411
            |:.||||:|||||||..||:.|...:|.....:|:|||||.:::|.:|:|||.::||...:..:.
Human   325 LHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSI 389

  Fly   412 HEAVDMIEEEFALIPETHLFLIVHNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHINTPLLWD 476
            .:.:|.|..:|.......|||::||||..|||..|:|.|:.:|:.:.||:|:|||||:|.||:||
Human   390 LDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWD 454

  Fly   477 QGKLCSFNFSWWDCTTMLPYTNETAFENSLLVQNSGELALSSMRSVFSSLTTNSRGIYMLIVKYQ 541
            ..|...||:.|::.||..|||.||::||||||:.||.|.|||:..|..|||.|:|||:.|::|||
Human   455 HAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQ 519

  Fly   542 LKNKGNATYQGMPFRDLYSSCREAFLVSSDLALRAQLTEFLDHKLVKSKRSVDGSEQLTIPIDGA 606
            |.|:.|.:|.|:.|:|.|..|||||||:|||.||||||||.||||:::|:..||.|.|.||:|..
Human   520 LDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNG 584

  Fly   607 LLQQFLEEQEKK 618
            .|..|||::|::
Human   585 TLTDFLEKEEEE 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc2	NP_731873.1	ORC2	160..614	CDD:227862	193/470 (41%)
Orc2	NP_731873.1	ORC2	296..604	CDD:282004	147/307 (48%)
ORC2	XP_011509554.1	ORC2	276..582	CDD:282004	147/307 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146558
Domainoid	1	1.000	299	1.000	Domainoid score	I1447
eggNOG	1	0.900	-	-		E1_COG5575
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4512
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2310
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1404162at2759
OrthoFinder	1	1.000	-	-		FOG0004739
OrthoInspector	1	1.000	-	-		oto91479
orthoMCL	1	0.900	-	-		OOG6_102887
Panther	1	1.100	-	-	LDO	PTHR14052
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R871
SonicParanoid	1	1.000	-	-		X3334
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790