DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc2 and orc2

DIOPT Version :9

Sequence 1:	NP_731873.1	Gene:	Orc2 / 41703	FlyBaseID:	FBgn0015270	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_596143.1	Gene:	orc2 / 2541159	PomBaseID:	SPBC685.09	Length:	535	Species:	Schizosaccharomyces pombe

Alignment Length:	549	Identity:	159/549 - (28%)
Similarity:	245/549 - (44%)	Gaps:	98/549 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 AKDLHLIQSEYNVAGTSMFGFNTPKK---RDAMALAALNATPCTPKTPKTPRLGVKTPDTKRKKS 175
            :.||.:::   ||:       :||||   .|...|.....||.||........|..|.|...|:.
pombe    32 SNDLKMVE---NVS-------STPKKGVLEDPSTLTPEVVTPRTPGHRIIKAKGAYTKDRSAKRR 86

  Fly   176 MDQPKTPAHVRTRVKKQIAKIVADSDED-----------FSGDESDFRPS---DEESSSSSSSSD 226
            ..:.:...|           ::.:.|::           :|.:.....||   ::||....:.|.
pombe    87 RGRIEIERH-----------LLGEFDDNVGSNSLLDVPLYSLEAEPLSPSVMLEDESMEGINQSP 140

  Fly   227 AGNSSDNDAADDEPKTPSRARRAIVVPVLPKTPSAARLR-------QSARAKKSNEFVPESDG-- 282
            .|.|.:....:|     :|:|.:        ||::..|.       :.|...:||.|...|.|
pombe   141 QGISVEKLGKED-----NRSRSS--------TPASPSLESHEFSESREAGLSQSNGFEARSHGTG 192

  Fly   283 ---YFHSHASSKILTSDHTLDRLKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWM 344
               ||...:..|  ||.:||.:|  |.|........:.||.|  |.|.....::......|.:|.
pombe   193 FDEYFDKFSQRK--TSSNTLSQL--PVLDNQVYLDTVKEICT--ETEQHTQTLVHFQSRNFHQWY 251

  Fly   345 CILNEGFNILLYGLGSKHQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPA 409
            ..|...||:|.||.|||...|.||..:.|....:.||.|:||.|.:|::|.|.. :.|:  ::||
pombe   252 FELVNNFNLLFYGFGSKEHFLSSFVEKKLPCFPIFVVKGYFPQLQLKNVLSSFL-EFLE--VTPA 313

  Fly   410 NPHEAVDMIEEEFALIPETHLFL-----IVHNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHI 469
              ....||:.:..::|......|     :|||:||..|.:.:.|:.|:.:|...|::.:||:||:
pombe   314 --ASVSDMLIQSLSIINSPSFSLGKIVFLVHNIDGESLIDERFQSALAAIASSKNVYFIASVDHV 376

  Fly   470 NTPLLWDQGKLCSFNFSWWDCTTMLPYTNETAFENSLLVQNSGELALS----SMRSVFSSLTTNS 530
            |..||||.....||||...|.||...|.|||.:||||.:   |...:|    :::.|..||..||
pombe   377 NFALLWDTSLESSFNFVMHDATTFARYYNETTYENSLGI---GRANVSNKEKAIKHVLYSLPANS 438

  Fly   531 RGIYMLIVKYQLK----------NKGNATYQGMPFRDLYSSCREAFLVSSDLALRAQLTEFLDHK 585
            |||:..::.:||:          .:|...  |:.:|..:..|...||.|::...|:|||||.||.
pombe   439 RGIFKFLLIHQLERMMDTQDFDARQGEKV--GIEYRSFFQKCSAEFLCSNEPNFRSQLTEFFDHN 501

  Fly   586 LVKSKRSVDGSEQLTIPIDGALLQQFLEE 614
            :::|||.|..||.|.:|....||:..||:
pombe   502 IIESKRDVSNSEILWVPYPKNLLEILLED 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc2	NP_731873.1	ORC2	160..614	CDD:227862	144/498 (29%)
Orc2	NP_731873.1	ORC2	296..604	CDD:282004	110/326 (34%)
orc2	NP_596143.1	ORC2	1..535	CDD:227862	159/549 (29%)
orc2	NP_596143.1	ORC2	207..519	CDD:282004	109/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I986
eggNOG	1	0.900	-	-		E1_COG5575
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I1156
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004739
OrthoInspector	1	1.000	-	-		oto102007
orthoMCL	1	0.900	-	-		OOG6_102887
Panther	1	1.100	-	-	LDO	PTHR14052
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R871
SonicParanoid	1	1.000	-	-		X3334
TreeFam	1	0.960	-	-
	12	11.850