Protein Alignment Kots and Tdrd7

DIOPT Version :10

• Sequence 1: NP_650324.1
• Gene: Kots / 41702
• FlyBaseID: FBgn0038191
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_006238169.1
• Gene: Tdrd7 / 85425
• RGDID: 619724
• Length: 1146
• Species: Rattus norvegicus
• Alignment Length: 974
• Identity: 173/974 - (17%)
• Similarity: 282/974 - (28%)
• Gaps: 417/974 - (42%)

  Fly    82 PCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVANVEAIERMTVNMQRC 146
            |.|.|..:..||.|..:|..|.:|..            .|:| ||:..:.:.
  Rat   271 PNVTPPASYTNKMDEVQNRIKEILDK------------HNNG-IWISKLPHF------------- 309

  Fly   147 MQNKKMIRMEGVREDTLVAISVGDKVHRGHVLTV---C---------QKKQEANVRMIDHGQIVA 199
               .|....|.:.:..|....     |..|:.||   |         ..|:|..:|.....:...
  Rat   310 ---YKEFYKEDLNQGVLQQFE-----HWPHICTVEKPCGGGQDLLLYPAKREQPLRSDQDPEKER 366

  Fly   200 TPFRDIYTIVPKMAESKAFAFRVQLPTNTG---VQDIKNLTLRMLGTKTSDGAYHVHLKPKMIIP 261
            .|        |..|.      |.::|:...   :.|:|.....:|| |.|.|.:          .
  Rat   367 PP--------PPPAP------RQEVPSKGSPAVMPDVKEKVAELLG-KYSSGLW----------A 406

  Fly   262 LSLPLEMLQLNPEVKVIRVFKANPKHNEPQLALLQINVMGHV---NADLNNRIAEKPRQPFTLPF 323
            .:||             :.|:...|...|:.||..:..:..|   |....|
  Rat   407 SALP-------------KAFEDMYKVKFPEDALKNLASLSDVCTINYISGN-------------- 444

  Fly   324 PEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIATDL-SRIPSELLGLPSRVF 387
             .||:|.:|..                 |.||..:.: ||.:.....|: |.|..|.|
  Rat   445 -TQKAILYAKL-----------------PLPTDKILK-DEAQAQGDFDIKSMIEQEYL------- 483

  Fly   388 AAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQ-----I 447
              |:|.::.|..:....::||       ||......|:.::           |:..|..     |
  Rat   484 --QIEKNMAESADDFVEDITV-------PPLVIPTEASPSV-----------LVVELSNTNDVVI 528

  Fly   448 SYLGHKY-WREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSI 511
            .|:|..| ..:.::.|.:         ||.|...|                 .:|....|.||.:
  Rat   529 RYVGKDYSAAQELMEDEM---------KEYYSRNP-----------------RVTPIQTVHVGQL 567

  Fly   512 VLVVSKQMGHFRGEILSKDSGLFEVMNVDTGATQKVELAE------------------------- 551
            :.|.:::....|.:|:|.|....:|..||.|..:.:|.::
  Rat   568 LAVNAEEDAWLRAQIISTDENKIKVCYVDYGFCENIEKSKAYRLNPRFCSLSFQATKCKLAGLEI 632

  Fly   552 ---------------------------------------------IRSSC------RFLE-NLPV 564
                                                         |.::|      |.|| :|.|
  Rat   633 LNDDPNLVKVVESLTCGKIFAVEILDKSDIPLVVLYDTSGEDDININATCLKAICDRSLEVHLQV 697

  Fly   565 CLM--RVQLQNVCNIPDAA----VPVN--NAAIQMLH-----------------------KLC-- 596
            ..|  .|::.|:|:  |..    ||..  |....:||                       |:|
  Rat   698 DAMYTNVKVTNICS--DGTLYCQVPCKGLNKLNDLLHKTEDYFHCKHMTSEYFISLPFCGKICLF 760

  Fly   597 -AQKELLKLNMVDATTS-TVDLLF-SSGDSRSLTTQMLPLIFTPVQEKAEVAPPKAASTPSQLPV 658
             .:.:.|::.:.:..:| .:|:.| .||:|.|:          .|.|..|: ||:.......:|
  Rat   761 HCKGKWLRVEITNVHSSRALDVQFLDSGNSTSV----------KVSELREI-PPRFLQEMLAIP- 813

  Fly   659 VTHKQQKVSPQSL--LLLDLP-PLPPSPPE------------SPFPADVTSTKSASHVLPIKRFL 708
                     ||::  .|.||| .:....|:            |.....||....|..|..:  :|
  Rat   814 ---------PQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKVDEARGVAYV--YL 867

  Fly   709 FDALPKNLAPLGDKVNLILMNAD-------------------------GLPQTGYITAAYFKDEK 748
            |  .|||.......:|..:.|||                         ..|..|....:..|...
  Rat   868 F--TPKNFPDPHRSINRQITNADLWKHQKDVFLSAVSAAASSPGNRNASTPAPGSPAESLRKSHP 930

  Fly   749 AAKEFEKILSLTSS------------QGACDHNVVPGYVP---NVGELCLAIYSE---------- 788
            .... :.:|..|||            ..:.:|..|  |||   :.|...:..:.|
  Rat   931 EVLR-KSVLDHTSSFSLEELPPPVHLSKSGEHMDV--YVPVACHPGHFVIQPWQEIHKLEVLMEE 992

  Fly   789 -------------------------DKNWYRGVCQEVKDN-MVKILFCDFGNTEYVAVRHVKPI 826
                                     :..|||.:.:.:..| :|.:...|:|..|.|.:|.|:|:
  Rat   993 MILYYSVSEERHIAVERDQVYAAKVENKWYRVLLKGILTNGLVSVYELDYGKHELVNIRKVQPL 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kots	NP_650324.1	zf-MYND	9..44	CDD:460312
		TUDOR	110..225	CDD:425754	19/126 (15%)
		TUDOR	465..573	CDD:425754	27/186 (15%)
		TUDOR	743..843	CDD:425754	24/135 (18%)
Tdrd7	XP_006238169.1	LOTUS_1_TDRD7	38..124	CDD:193600
		LOTUS_2_TDRD7	283..349	CDD:193587	16/99 (16%)
		LOTUS_3_TDRD7	388..452	CDD:193588	20/102 (20%)
		Tudor_SF	540..637	CDD:470623	19/122 (16%)
		Tudor_TDRD7_rpt2	701..840	CDD:410499	32/161 (20%)
		Tudor_TDRD7_rpt3	978..1068	CDD:410500	13/79 (16%)