DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and Tdrd1

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_006527536.1	Gene:	Tdrd1 / 83561	MGIID:	1933218	Length:	1173	Species:	Mus musculus

Alignment Length:	1008	Identity:	200/1008 - (19%)
Similarity:	336/1008 - (33%)	Gaps:	289/1008 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TCVVCGTPTRLMCQRCGEP-YCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQS----VE 67
            ||..||....|.|.:|.:. ||:..||:.||..|..:         |||:|.:||.::.    .|
Mouse   162 TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTI---------CRPVQQSLNKLEDNKSPFE 217

  Fly    68 NQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVAN 132
            .:....|:......|.|...:....:..:..:.|...|...|| .|..||..::....: :.:.:
Mouse   218 TKAIEVKSEQVDCPPGVTKEITAGAERVMFSDLRSLQLKKTME-IKGTVTEFKHPSNFY-IQLYS 280

  Fly   133 VEAIERMTVNMQRCMQNKKMIRMEGVREDTLVAI---------SVGDKVHRGHVLTVCQKKQEAN 188
            .|.:|    ||.:...:.|......|.||..:.:         :|....:|..|..|...:::|:
Mouse   281 SEVLE----NMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAH 341

  Fly   189 VRMIDHGQIVATPFRDIYT-------------------IVPK--------MAESKAFAFR----- 221
            |..||:|.....|...::.                   ::|.        :|..||..|.
Mouse   342 VLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSV 406

  Fly   222 --------------VQLPTNTGVQDIKNLTLRM-LGTK------TSDGAYHVHLKP--KMIIPLS 263
                          |.|...:..:.:.::.:.| .|.|      |.....|..|:.  ::.:...
Mouse   407 KVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSSTEQSVDHSALEDVGRVTVESK 471

  Fly   264 LPLEMLQLNPEVKVIRV---FKANPKH-NEPQLALLQINVMGHVNADLNNRIAEK-----PRQPF 319
            :..:...|.|:|..:.|   |.....| ..|:....|....||..|:|...::|.     ||..|
Mouse   472 IVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDF 536

  Fly   320 TLPFPEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIAT--DLSRIPSELLGL 382
               :|....:..|.....:.:.||.:|.:..:  .:.||..:|.|...|.:  .|..|..:||.|
Mouse   537 ---YPTIGDVCCAQFSEDDQWYRASVLAYASE--ESVLVGYVDYGNFEILSLKRLCPIIPKLLDL 596

  Fly   383 PSRVFAAQLEDSVPE-ELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQ 446
            |.:.....|....|. .:.|..|...:|..:.|                        |::| :..
Mouse   597 PMQALNCVLAGVKPSLGIWTPEAVCVMKEMVQN------------------------RMVT-VRV 636

  Fly   447 ISYLGHKYWRE-------PIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSS 504
            :..||.:...|       |.|..|...|....:.||        |..|:             |.|
Mouse   637 VGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKE--------KDVAD-------------KGS 680

  Fly   505 DVSVGSIVLVVSKQMGHFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSCRFLENLPVCLMRV 569
            .:...|:.|.:.                         |..:.:|...:..:.....::.||:|..
Mouse   681 SMHTASVPLAIE-------------------------GPAEALEWTWVEFTVDETVDVVVCMMYS 720

  Fly   570 QLQNVCN-IPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDS---RSLTTQM 630
            ..:..|: :.|.|:...:...|.|...||||   ..|...|........|.|||.   |:|..::
Mouse   721 PGEFYCHFLKDDALEKLDDLNQSLADYCAQK---PPNGFKAEIGRPCCAFFSGDGNWYRALVKEI 782

  Fly   631 LP--------LIFTPVQEKAEVAPPKAASTPSQLPVVTHKQQKVSPQSLL---------LLDLPP 678
            ||        :.:..|:|                 |.|.:.|.:.||.||         |:|:.
Mouse   783 LPSGNVKVHFVDYGNVEE-----------------VTTDQLQAILPQFLLLPFQGMQCWLVDIQ- 829

  Fly   679 LPPS-----PPESPFPADVTSTKSASHVLPIK--------RFLFDALPKNLAPLGDKVNLILMNA 730
             ||:     ...:.|.|.|...|..:.|:.|.        ..|....||.::.:..:..|:|  .
Mouse   830 -PPNKHWTKEATARFQACVVGLKLQARVVEITANGVGVELTDLSTPYPKIISDVLIREQLVL--R 891

  Fly   731 DGLPQTGYIT----------------------------------AA-----------YFKDEKAA 750
            .|.||...::                                  ||           |....:.:
Mouse   892 CGSPQDSLMSRPANQHKQIDSHRVQASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMS 956

  Fly   751 KEFEKILSLTSSQGACDH----NVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCD 811
            :..||:..|.:.  ..:|    ...|.|.|..|:.|.|.|:.|..|||.:..|..::.||:|:.|
Mouse   957 ENQEKLCVLAAE--LLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYAD 1019

  Fly   812 FGNTEYVAVRHVKPI-SQDLLIAVNVTKCYING 843
            :||.|.:.:..|:|| :..|.:...:.:|.:.|
Mouse  1020 YGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009	13/35 (37%)
		TUDOR	109..225	CDD:278965	29/170 (17%)
		TUDOR	457..573	CDD:278965	18/122 (15%)
		TUDOR	718..843	CDD:278965	36/174 (21%)
		TUDOR	779..825	CDD:119391	17/45 (38%)
Tdrd1	XP_006527536.1	zf-MYND	163..199	CDD:366792	13/44 (30%)
		TUDOR	262..378	CDD:366171	21/120 (18%)
		TUDOR	493..606	CDD:366171	27/117 (23%)
		TUDOR	718..825	CDD:366171	29/126 (23%)
		TUDOR	936..1050	CDD:366171	31/115 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10753
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100