Protein Alignment CG9925 and TDRD1

DIOPT Version :9

• Sequence 1: NP_650324.1
• Gene: CG9925 / 41702
• FlyBaseID: FBgn0038191
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001372292.1
• Gene: TDRD1 / 56165
• HGNCID: 11712
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 1082
• Identity: 226/1082 - (20%)
• Similarity: 385/1082 - (35%)
• Gaps: 316/1082 - (29%)

  Fly     8 TCVVCGTPTRLMCQRCGEP-YCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQ---SVEN 68
            ||..||....|.|.:|.:. ||:..||:.||..|.         :.|||:||..:.::   |:|.
Human   169 TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSAHS---------IVCRPVQPNFHKLENKSSIET 224

  Fly    69 QVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVAN- 132
            :......::..|:. |...:|:..:..:..:.|...|...|| .|..||..::.|..:|...::
Human   225 KDVEVNNKSDCPLG-VTKEIAIWAERIMFSDLRSLQLKKTME-IKGTVTEFKHPGDFYVQLYSSE 287

  Fly   133 -VEAIERMTVNMQRCMQN---KKMIRMEGVREDTLVAISVGDKVHRGHVLTVCQKKQEANVRMID 193
             :|.:.:::.:::....|   |..|.::|  |..:...:|....:|..:..|..::::|:|..||
Human   288 VLEYMNQLSASLKETYANVHEKDYIPVKG--EVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYID 350

  Fly   194 HGQIVATPFRDIY-------------------TIVPKMA-------------------------- 213
            :|.....|...||                   .::|...
Human   351 YGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDI 415

  Fly   214 ---ESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKP------------------- 256
               |...||..|:|| |:|         ::|.....:..|  .|||
Human   416 LEEEVVTFAVEVELP-NSG---------KLLDHVLIEMGY--GLKPSGQDSKKENADQSDPEDVG 468

  Fly   257 KMIIPLSLPLEMLQLNPEVKVIRV---FKANPKH-NEPQLALLQINVMGHVNADLNNRIAE---- 313
            ||....::.::...|.|:|..:.|   |.....| ..|:....|....|...|:|...:::
Human   469 KMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQ 533

  Fly   314 -KPRQPFTLPFPEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIATDLSRIP- 376
             .||..|   :|....|..|.....:.:.||.:|.:..:  .:.||..:|.|...|.:.:...|
Human   534 LPPRSDF---YPAIGDICCAQFSEDDQWYRASVLAYASE--ESVLVGYVDYGNFEILSLMRLCPI 593

  Fly   377 -SELLGLPSRVFAAQLEDSVPE-ELETQGAELTVKFKLDNKPPKEKL--RAANAAL-----NSKG 432
             .:||.||.:.....|....|. .:.|..|...:|..:.||....|:  :..|::|     .|:.
Human   594 IPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSET 658

  Fly   433 EQICMARLIT----FLGQISYLGHK----------------------YWREPIVHDSI-VFISHL 470
            ..:.:::::.    .:|:.|.:..|                      .|.|..|..:: |.:..:
Human   659 PHVSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVI 723

  Fly   471 VSFKEVY--ISTPDA-KQYAEIFKRLEYKCATITKSSDVSVGSIVLVVSKQMGHFRGEI------ 526
            .|..|.|  :...|| |:..::.|.|...|.                 .|....|:.||
Human   724 YSPGEFYCHVLKEDALKKLNDLNKSLAEHCQ-----------------QKLPNGFKAEIGQPCCA 771

  Fly   527 -----------LSKD---SGLFEVMNVDTGATQKVELAEIRS-SCRFLENLPVCLMRVQLQNVCN 576
                       |.|:   :|..:|..||.|..::|...|:|. |..|| |||...:|.||
Human   772 FFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL-NLPFQGIRCQL----- 830

  Fly   577 IPDAAVPVNNAAIQMLHK-----------LCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQM 630
                      |.||..:|           :|.....|:..:|:.|.:.:.:     :...|:| .
Human   831 ----------ADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGV-----ELTDLST-C 879

  Fly   631 LPLIFTPVQEKAEVAPPKAASTPSQLP---VVTHKQQKVSPQSL---------LLLDLPPLPPSP 683
            .|.|.:.|.....:. .|:||....||   :|...:.:|..|.|         ..::||
Human   880 YPRIISDVLIDEHLV-LKSASPHKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELP------ 937

  Fly   684 PESPFPADVTSTKSASHVLPIKRFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEK 748
                    |..|..|:.:..|...||.||||                 |:|:         ..||
Human   938 --------VDKTIQANVLEIISPNLFYALPK-----------------GMPE---------NQEK 968

  Fly   749 AAKEFEKILSLTSSQGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCDFG 813
            ......::|...::..:     .|.|.|.:|:.|.|.|:.|..|||.|.....|..|::|:.|:|
Human   969 LCMLTAELLEYCNAPKS-----RPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYG 1028

  Fly   814 NTEYVAVRHVKPI-SQDLLIAVNVTKCYINGFDK------------SKNFAALEQFLVRKIRFL- 864
            |.|.:.:..|:|| |..|.:...:.:|.:.|..:            .||| .|.|.::..::.:
Human  1029 NIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNF-MLNQNVMLSVKGIT 1092

  Fly   865 -----CGVKKGPEPDT-----RLITI-------PDMETILNT 889
                 ..|:|..|..|     :|:|.       |..::.|||
Human  1093 KNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNT 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009	13/35 (37%)
		TUDOR	109..225	CDD:278965	29/168 (17%)
		TUDOR	457..573	CDD:278965	35/140 (25%)
		TUDOR	718..843	CDD:278965	30/125 (24%)
		TUDOR	779..825	CDD:119391	17/45 (38%)
TDRD1	NP_001372292.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..138
		zf-MYND	170..206	CDD:396356	13/44 (30%)
		Tudor_TDRD1_rpt1	268..396	CDD:410479	22/129 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..469		0/18 (0%)
		Tudor_TDRD1_rpt2	517..598	CDD:410480	18/85 (21%)
		TUDOR	715..832	CDD:395449	33/149 (22%)
		Tudor_TDRD1_rpt4	944..1059	CDD:410482	38/145 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10871
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310250at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.110