DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9925 and tdrd1

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	921	Identity:	191/921 - (20%)
Similarity:	319/921 - (34%)	Gaps:	273/921 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTCVVCGTPTRLMCQRCGEP-YCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQSVENQV 70
            |.|..|.....|.|.||.:. ||:..||..||..||.||  .|.:.|....:|  ...::|....
Zfish    81 KLCNYCSHQGNLRCTRCKKTCYCSVACQTQDWIAHRHVC--KPSIPEVTSEKP--KESKAVPYAN 141

  Fly    71 ALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGME----FFKC----------------- 114
            .|..|:.|      |.:|....|.....:..|.::..|.|    ||:|
Zfish   142 GLGGTQAK------EISVDAQPKRIYRRDLHKKVVSKGSEIKVLFFRCSSLVCYPSIDTLPHTKC 200

  Fly   115 ---RVTFMENDGPIWVVHV---ANVEAIERMTVNMQR--CMQNKKMIRMEGVREDTLVAISVGDK 171
               .|..:.|.| ::.:|.   ..:|:::::|..:|:  |....:..:.| |.|...|..|:...
Zfish   201 LQGTVIDLRNPG-MFSIHCQCEEMIESLKKITQQLQKTYCSSFAQEYKPE-VGELCAVKFSLDQN 263

  Fly   172 VHRGHVLTVCQKKQEANVRMIDHG--QIVA----TPFRDIYTIVPKMAESKAFAFRVQLPTNTGV 230
            .:|..:..|...::.|.|..||.|  :.||    .|..:....||..|.....|
Zfish   264 WYRAEIQAVDVARKTAGVFYIDFGNEENVALDHIRPLSENIDAVPPFALQCCIA----------- 317

  Fly   231 QDIKNLTLRMLGTKTSDGAYHVHLKPKMIIPLSLPLEMLQLNPEVKVIRVFKANPKHNEPQLALL 295
             .:|.||    |:.|.:....|.   ::|...||...:|.:..:..::.|...
Zfish   318 -GVKPLT----GSWTGECCIAVR---QLIAGKSLTFTVLDIMNDGDLLAVDSL------------ 362

  Fly   296 QINVMG-HVNADLNNRIAEKPRQPFTLPFPEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVY 359
             ::.:| ||:                                      .||:|.      :|.:
Zfish   363 -VSTLGKHVS--------------------------------------TFLIDQ------SYAI- 381

  Fly   360 EMDEGRVSIATDLSRIPSELLGLPSRVFAAQLEDSVPEELETQ---GAELTVKFKLDNKPPKEKL 421
                                            ::.||.:.:|:   .:.||..|        |..
Zfish   382 --------------------------------KEDVPVKTQTEHSINSLLTASF--------ENF 406

  Fly   422 RAANAALNSKGEQICMARLITFLGQISYLGHKYWREPI---VHDSI-VFISHLVSFKEVYI-STP 481
            :..:...|...|    ||.               .||:   |.||. ..::||.|..|:.. ...
Zfish   407 KRFSGGKNENSE----ARP---------------PEPLTQGVGDSFTAVVTHLQSPSEILCQKLE 452

  Fly   482 DAKQYAEIFKRLEYKCATITKSSDV--SVGSIVL-VVSKQMGHFRGEILSKDSGLFE----VMNV 539
            :|....::...|...|:....|.|.  :.|::.. :.|:....:|.::|:..|   |    |..:
Zfish   453 NASIIQQLQMNLRVHCSNTAASDDFRPAPGTVCCSLFSEDNQWYRAKVLAYSS---EDRVCVGYI 514

  Fly   540 DTGATQKVELAEIRSSCRFLENLPVCLMRVQLQNVCNIPDAAVPVNNAAIQMLHKLC---AQKEL 601
            |.|.:::|||..:|...:.|..|....:...|..:.::.|..  .:.|.:.:.|.:|   .:.|:
Zfish   515 DFGNSEEVELNRLRPISKELLALATQAIPCSLAGIKSLTDTW--SDEAVLMLKHLVCNRFIRVEI 577

  Fly   602 LKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQ--EKAEVAPPKAASTPSQLPVVTHKQQ 664
            |......|..|.:|  .||....|:|..::.:.|..::  |..:..|..|.||
Zfish   578 LGKKDGRALVSMID--ESSDPQASVTELLVNMGFAAIESVETKKNEPDPATST------------ 628

  Fly   665 KVSPQSLLLLDLPPLPPSPPESPFPADVTSTKSASHVLPIKRFLFDALPKNLAPLGDKVNLILMN 729
                      ::|||  |.|.      |...:.....||     ||         |.||.|::..
Zfish   629 ----------EIPPL--SQPV------VEKLEWTGAELP-----FD---------GQKVELVIST 661

  Fly   730 ADGLPQTGYITAAYFK-DEKAAKE--FEKILSLTSSQGACDHNVVPGYVPNVGELCLAIYSEDKN 791
            ...|.:  :....|.| ||....|  ||.:..       |:....| :.|.|||.|.|:::.|..
Zfish   662 LKSLDE--FYCYNYSKTDEHTLTEMSFELMKH-------CESERAP-FTPIVGEPCCALFTGDAR 716

  Fly   792 WYRGVCQEV-KDNMVKILFCDFGNTEYVAVRHVKPISQDLL-IAVNVTKCYINGFDKSKNFAALE 854
            |||.:..|| .:...::.|.|:||:..|...|:|.|:|.|| :.....:|::.|.:..:.....|
Zfish   717 WYRAMVLEVCGEGKARVCFVDYGNSCEVDAAHLKAITQSLLKLPFQAIRCWLAGVEPVEGQWKKE 781

  Fly   855 QFLVRKIRFLC 865
            ..|  :.:.||
Zfish   782 AML--RFQALC 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009	14/35 (40%)
		TUDOR	109..225	CDD:278965	31/150 (21%)
		TUDOR	457..573	CDD:278965	30/127 (24%)
		TUDOR	718..843	CDD:278965	38/129 (29%)
		TUDOR	779..825	CDD:119391	16/46 (35%)
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734	14/35 (40%)
		TUDOR	210..318	CDD:306940	26/121 (21%)
		TUDOR	429..548	CDD:306940	28/121 (23%)
		TUDOR	652..770	CDD:306940	38/127 (30%)
		TUDOR	908..1020	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11346
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310250at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.110