DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and vret

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_651092.1	Gene:	vret / 42695	FlyBaseID:	FBgn0263143	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	679	Identity:	148/679 - (21%)
Similarity:	240/679 - (35%)	Gaps:	139/679 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 YTIVPKMAESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKPKMIIPLSLPLEMLQ 270
            |.:|||   |..:.....|....|...||.:..|.|..     .|.|:.  :.|..|....:.:|
  Fly    60 YLVVPK---SSPYVTEKMLINFFGRALIKEMEFRRLSR-----VYFVYF--ENIASLETAQQRVQ 114

  Fly   271 LNPEVKVIRVFKANPKH-----NEPQLALLQINVMG-HVNADLNNRIAEKPRQPFTLPFPEQKSI 329
            ..|  .:|:.....|:.     ::|..:...:...| .::|.....:......|.:.........
  Fly   115 RYP--NLIKCITGRPQKEREITSDPVTSTEPMPTPGPAISATERTPVNHNREVPISTGGQNHPEF 177

  Fly   330 FFAATRTKNGYRRAFLL---DHIMKPRPTYLVYEMDEGRVSIATDLSRIPSELL------GLPSR 385
            |.....||:.|:|..||   |.|.:.......:.::...:....|.:|||..:|      .:|..
  Fly   178 FRPPLVTKDDYKRGSLLATNDPIQRYLNVKYEFALERHDIYKLKDETRIPQVVLHFRSGRTIPLS 242

  Fly   386 VFAAQLEDSVPEELETQGAELTV------KF-KLDNKPPKEKLRAANAALNSKGEQICMARLITF 443
            ..|...||.....||...::..|      .| ||...|.......|:.|...|  |.|....|..
  Fly   243 TVAVTEEDKTKSLLEDGVSKCVVCQNWTDTFCKLCKMPFCNASCFADVAEQHK--QACGKGEILN 305

  Fly   444 LGQISYLGHKYWREPI-VHDSIVFISHLVSFKEVYISTPDAK---QYAEIFKRLEY--KCATITK 502
            |.:  .:|.||.:..: ...|.|.|:.......||:.:.|.:   .|..:...:..  |.|:..:
  Fly   306 LDE--KVGRKYPKPGLPPSGSKVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVMMLGKDASKLQ 368

  Fly   503 SSDVSVGSIVLVVSKQMGHF-RGEILSKDSGLFE--VMNVDTGATQKVELAEIRSSCRFLENLPV 564
            |:.| .|.|||.  |..||. |..:|:.|: :.|  |:.:|.|:.:..:|..:.....:|..|..
  Fly   369 STPV-CGQIVLY--KFEGHMSRAMVLNVDN-IKEIYVVFIDFGSVEVTQLERLYECSSYLAGLTC 429

  Fly   565 CLMRVQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTV-DLLFSSGDSRSLTT 628
            ..:.|:|:.|   |...|..|                ::..|.:...|.| ::.:|   ||...|
  Fly   430 YPVAVKLRGV---PRRFVGPN----------------IREVMYELDQSLVFNIKYS---SREYDT 472

  Fly   629 QMLPLIFTPVQEKAEVAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVT 693
                                  |...|:.|:|......|...|....|.|:.||..:..:..
  Fly   473 ----------------------SKGMQVVVMTEIDINRSLNRLFKTILTPVEPSVSDLGYKE--- 512

  Fly   694 STKSASHVLPIKRFLFDALPKNLAPLGDKVNLILMNADGLPQTGY-----ITAAY--FKDEKAAK 751
                            |.||......|..:|:::|: :...|.|:     |..||  .|.::..:
  Fly   513 ----------------DCLPYIPLHCGKNINVVVMD-NTFIQCGFIYCTSIDLAYEVTKMQRDIQ 560

  Fly   752 EF-EKILSLTSSQGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQE-VKDNMVKILFCDFGN 814
            |: |||....:            |.|.:.|||:|.|  :..|.||:..| |.|....|||.|:||
  Fly   561 EYGEKIAKCAT------------YAPPINELCIAKY--EGKWRRGLSVELVGDGYPSILFIDYGN 611

  Fly   815 TEYVAVRHVKPISQDLLIAVNVTKCYING 843
            .....|..::|.....:..:..|:..:.|
  Fly   612 IVPTHVTDIRPYPPQFIFPIMTTQLDLIG 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009
		TUDOR	109..225	CDD:278965	5/18 (28%)
		TUDOR	457..573	CDD:278965	30/124 (24%)
		TUDOR	718..843	CDD:278965	35/133 (26%)
		TUDOR	779..825	CDD:119391	18/46 (39%)
vret	NP_651092.1	TUDOR	320..438	CDD:278965	30/121 (25%)
		TUDOR	374..419	CDD:119391	15/47 (32%)
		TUDOR	520..640	CDD:278965	35/134 (26%)
		TUDOR	577..622	CDD:119391	18/46 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0014298
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.100