DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and Tdrd6

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001178512.1	Gene:	Tdrd6 / 316254	RGDID:	1305956	Length:	2136	Species:	Rattus norvegicus

Alignment Length:	896	Identity:	170/896 - (18%)
Similarity:	301/896 - (33%)	Gaps:	306/896 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 AKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVANVEAIE 137
            |..:::||...:|..|::|:...:.....        .|:..:|.|:::....|:....:.....
  Rat   464 AAFQSQSPAEEMEEEVSLPSLRSIRLKMN--------TFYDAQVEFVKSPSEFWIRLRKHKNTFS 520

  Fly   138 RMTVNMQRCMQNKKMIRMEGV----REDTLVAISVGDKVHRGHVLTVCQKKQEANVRMIDHGQIV 198
            ::|..|  |.......:::||    ..|.|..:...:..:...::|....| ..:|.::|.|...
  Rat   521 KLTKRM--CSFYSSASKLDGVILKPEPDDLCCVKWKENGYYRAMVTRLDSK-SVDVFLVDRGNSE 582

  Fly   199 ATPFRDIYTIVPKMAESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKPKMIIPLS 263
            ...:.|:..::|:        || |||.                                   |:
  Rat   583 NVDWCDVRMLLPQ--------FR-QLPI-----------------------------------LA 603

  Fly   264 LPLEMLQLNP-----EVKVIRVFKANPKHNEPQLALLQINVMGHVNADLNNRIAEKPRQPFTLPF 323
            |...:..:.|     ..:.|..||....|.|     |.::::            :|..:.:.:..
  Rat   604 LKCTLADIWPLGKTWSQEAISFFKKTVLHKE-----LVVHIL------------DKQDRQYVIEI 651

  Fly   324 PEQKSIFFAATRTKNGYRRAFLLDHIMK--PRPTYLVYEMDEGRVSIATDLSRIPSELLGLPSRV 386
            .::       :||..        ::|.|  .:..|..::..|.:.:|     |:.:...|..|..
  Rat   652 LDE-------SRTGE--------ENISKVIAQAGYAKFQEFETKENI-----RLSAHSPGHVSGH 696

  Fly   387 FAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISYLG 451
            |.|: ...:|...:.:|.:   |.|.|||...:....|..:|::           ...||.:
  Rat   697 FIAE-SSKIPSVKKVEGDQ---KAKNDNKTLSDPEALATVSLSN-----------ISTGQTA--- 743

  Fly   452 HKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLV-V 515
              ..:|.:..|..:.:.:|:..|      ||.             |.    ..::.|||.|.| |
  Rat   744 --QDKEKVTSDPTLLMLNLLKTK------PDC-------------CG----KGELEVGSTVEVKV 783

  Fly   516 S--KQMGHFRGEILSKDSGLFEVM--------------NVDTGATQKVELAEIR------SSCRF 558
            |  :..|.|..:::....|...:|              ..||.|......|..|      |..:.
  Rat   784 SHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSEPSPYEGDTRACLAKRTANGRWSRALISGAQS 848

  Fly   559 LENLPVCLMR------VQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLK----------LNMV 607
            ||::.|..:.      |.::::.::.|....|...|.:     |:...|::          ...:
  Rat   849 LEHVRVVFVDYGDKDVVSMKDILSVSDVFFKVRAQAFR-----CSLYNLIQPTGENPFVWDERAI 908

  Fly   608 DATTSTVDLLFSSGDSRSLTTQMLPL-----------IFTPVQEKAEVAPPKAASTPSQLPVVTH 661
            .|.|..:|..:.:......|...|..           :.||.|........|..:.|.:|
  Rat   909 QAFTGFIDNAWQNNLELKCTIFALASRHEEECFNVVDLLTPFQSACHFLVEKRLARPVKL----- 968

  Fly   662 KQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTKSASHVLPIKRFLFDALPKNLAPLGDKVNLI 726
              ||            ||.||       ..:.|...::|.|.|               |.:..:.
  Rat   969 --QK------------PLEPS-------VQLHSYYYSTHDLKI---------------GSEELVY 997

  Fly   727 LMNADGLPQTGYITAAYFKDEKAAKEF--------EKILSLTSSQGACDHNVVPGYVPNVGELCL 783
            :.:||. |.|.|...|  ::....::.        :.:|:|.:|      .:||      |.|||
  Rat   998 ITHADD-PWTFYCQLA--RNTNILEQLSYHIMQLSKVLLNLRTS------TLVP------GTLCL 1047

  Fly   784 AIYSEDKNWYRGVCQEVKDNMVKILFCDFGNTEYVAVRHVKPISQD----LLIAVNVTKCYING- 843
            |.|: |.|||||:..|.:.:  |:.|.||||| |||..|:.||.:|    ||:.:...||.::.
  Rat  1048 AKYT-DGNWYRGIIIEKEPS--KVFFVDFGNT-YVASDHLLPIPRDAYDVLLLPMQAVKCSLSDI 1108

  Fly   844 ----------------FDKSKNFAALEQFLVRKIRFLCGVKKGPEPDTRLI 878
                            .|||     |:..:|.|           :||.|||
  Rat  1109 PHHIPEEVTAWFQETVLDKS-----LKALVVAK-----------DPDGRLI 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009
		TUDOR	109..225	CDD:278965	21/119 (18%)
		TUDOR	457..573	CDD:278965	28/144 (19%)
		TUDOR	718..843	CDD:278965	43/136 (32%)
		TUDOR	779..825	CDD:119391	24/45 (53%)
Tdrd6	NP_001178512.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965
		TUDOR	313..359	CDD:119391
		TUDOR	489..610	CDD:278965	25/175 (14%)
		TUDOR	547..591	CDD:119391	7/44 (16%)
		TUDOR	775..891	CDD:278965	25/120 (21%)
		TUDOR	827..870	CDD:119391	8/42 (19%)
		TUDOR	988..1107	CDD:278965	45/152 (30%)
		TUDOR	1043..1085	CDD:119391	24/45 (53%)
		TUDOR	1310..1429	CDD:278965
		TUDOR	1363..1407	CDD:119391
		TUDOR	1523..1645	CDD:278965
		TUDOR	1578..>1616	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100