DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and Tdrd1

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_038959137.1	Gene:	Tdrd1 / 292129	RGDID:	1306140	Length:	1174	Species:	Rattus norvegicus

Alignment Length:	992	Identity:	208/992 - (20%)
Similarity:	349/992 - (35%)	Gaps:	255/992 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TCVVCGTPTRLMCQRCGEP-YCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQ------- 64
            ||..||....|.|.:|.:. ||:..||:.||..|..:         |||:|.:|:.::
  Rat   161 TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTI---------CRPVQQSLHKLEDNKSPFE 216

  Fly    65 ----SVEN-QVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGP 124
                .|:| |||.....||......|..        :..:.|...|...|| .|..||..::.|.
  Rat   217 TKTIDVKNEQVACPLGVTKEMTAGAERV--------MFSDLRSLQLRKSME-IKGTVTEFKHPGH 272

  Fly   125 IWVVHVAN--VEAIERMTVNMQRCMQNKKMIRMEG---VREDTLVAISVGDKVHRGHV---LTVC 181
            .:|...::  :|.:.:::.:::....|  |:..:|   |:.:..||....|:.....|   :.|.
  Rat   273 FYVQLYSSEVLEYMNQLSASLKETYAN--MVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL 335

  Fly   182 QKKQEANVRMIDHGQIVATPFRDIYT-------------------IVPKMAE--------SKAFA 219
            |||  |:|..||:|.....|...|:.                   :||...|        .||..
  Rat   336 QKK--AHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVAVKALL 398

  Fly   220 FR-------VQLPTNTGVQDIKNLTLRMLGTKTSDGAYHV------HLKP--------------- 256
            |.       |.:....|:....::.|:..|.:..    ||      .:||
  Rat   399 FEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLD----HVLVEMGYGVKPDEPSSKKQSMDPGTS 459

  Fly   257 ----KMIIPLSLPLEMLQLNPEVKVIRV---FKANPKH-NEPQLALLQINVMGHVNADLNNRIAE 313
                ::.....:..|...|.|.|..:.|   |.....| ..|:....|....||..|:|...::|
  Rat   460 EDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSE 524

  Fly   314 -----KPRQPFTLPFPEQKSIFFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIAT--D 371
                 .||..|   :|....:..|.....:.:.||.:|.:..:  .:.||..:|.|...|.:  .
  Rat   525 YCSHVTPRSDF---YPTIGDMCCAQFSEDDQWYRASVLAYASE--ESVLVGYVDYGNFEILSLKR 584

  Fly   372 LSRIPSELLGLPSRVF---AAQLEDSV----PEEL-----ETQGAELTVK----------FKLDN 414
            |..|..:||.||.:..   .|.::.|:    ||.:     ..|...:||:          .:|.:
  Rat   585 LCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKAVQNRMVTVRVVGMQGTRALVELVD 649

  Fly   415 KPPKEKLRAANAALNS------------KGEQICMARL-ITFLGQISYLGHKYWREPIVHDSI-V 465
            |.....|.|:.|.|:|            ||.....:.: :...|.:..| ...|.|..|.::: |
  Rat   650 KSVAPHLSASKALLDSGFAIEEKDIVADKGSSARASNVPLAVEGAVEVL-EWTWVEFTVDETVDV 713

  Fly   466 FISHLVSFKEVY---ISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLVVSKQMGHFRGEI- 526
            .:..:.|..|.|   :.....|:..::.|.|...||                 .|....|:.|:
  Rat   714 MVCMMHSPGEFYCHCLKDDALKKLDDLNKSLADYCA-----------------QKPPNGFKAEVG 761

  Fly   527 ----------------LSKD---SGLFEVMNVDTGATQKVELAEIRS-SCRFL----ENLPVCLM 567
                            |.|:   ||..:|..||.|..::|...::.: :.:||    :.:...|:
  Rat   762 RPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLV 826

  Fly   568 RVQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLP 632
            .:|.:|.....:|........:.:  ||.|:...:..|.|....:.:...:....|..|.|:.|.
  Rat   827 DIQPKNKHWTKEATARFQACVVGL--KLQARVVEITENGVGVELTDLSTPYPKIISDVLITEHLV 889

  Fly   633 LIFTPVQEKAEVAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTKS 697
            |.....|:...::.|            .:|..::..||     :...||:.........|..|..
  Rat   890 LRCGSPQKDELMSRP------------ANKHNQIDSQS-----VQASPPAEQWKTIELPVNKTVP 937

  Fly   698 ASHVLPIKRFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEKILSLTSS 762
            |:.:..|...||.|:|..:....:|:.:             :||...:...|.|.
  Rat   938 ANVLEIISPTLFYAIPSEMPENQEKLCV-------------LTAELLEHCNAQKG---------- 979

  Fly   763 QGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCDFGNTEYVAVRHVKPI- 826
                    .|.|.|..||.|.|.|:.|..|||.:..|..|:.||:|:.|:||.|.:....|:||
  Rat   980 --------QPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPIT 1036

  Fly   827 SQDLLIAVNVTKCYING 843
            :..|.:...:.:|.:.|
  Rat  1037 ASHLQLPFRIIRCSLEG 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009	13/35 (37%)
		TUDOR	109..225	CDD:278965	34/157 (22%)
		TUDOR	457..573	CDD:278965	27/144 (19%)
		TUDOR	718..843	CDD:278965	31/125 (25%)
		TUDOR	779..825	CDD:119391	19/45 (42%)
Tdrd1	XP_038959137.1	zf-MYND	162..198	CDD:396356	13/44 (30%)
		Tudor_TDRD1_rpt1	262..391	CDD:410479	27/132 (20%)
		Tudor_TDRD1_rpt2	512..593	CDD:410480	20/85 (24%)
		TUDOR	709..825	CDD:395449	23/132 (17%)
		Tudor_SF	938..1053	CDD:413384	37/145 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310250at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110