DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9925 and TDRD6

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001010870.1	Gene:	TDRD6 / 221400	HGNCID:	21339	Length:	2096	Species:	Homo sapiens

Alignment Length:	933	Identity:	174/933 - (18%)
Similarity:	326/933 - (34%)	Gaps:	307/933 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKSEEKTCVVCGTPTRLMCQRCGEPYCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQS 65
            :.|:...|.||....|.|:.|                ::.::..:..|.:..|..::|..:....
Human   719 VSKALSDTTVVTNGSTELVVQ----------------EKVKRASVYFPLMQNCLEIKPGSSSKGE 767

  Fly    66 VENQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHV 130
            :|                |..||.|                        ||:::||.|..|....
Human   768 LE----------------VGSTVEV------------------------RVSYVENPGYFWCQLT 792

  Fly   131 ANVEAIERMTVNMQRCMQNKKMIRMEGVREDTLVAI---SVGDKVHRGHVLTVCQKKQEANVRMI 192
            .|::.::.:..::|...:|.....    :.:||..:   :|..:..|. :::..|..:..||..:
Human   793 RNIQGLKTLMSDIQYYCKNTAAPH----QRNTLACLAKRTVNRQWSRA-LISGIQSVEHVNVTFV 852

  Fly   193 DHGQIVATPFRDIYTIVPKMAESKAFAFRVQL-----PT--NTGVQDI---------------KN 235
            |:|.......::||:|..:..:.||.|||..|     |.  |..|.|:               ||
Human   853 DYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQNPFVWDVKAIQAFNEFIDNAWQKN 917

  Fly   236 LTLR----MLGTKTSD------------GAYHVHLKPKMIIPLSL--PLE-MLQLNPEVKVIRVF 281
            |.|:    .|.:...:            .|.|..::.::..|:.|  ||| .:||:.........
Human   918 LELKCTIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDM 982

  Fly   282 KANPKH-------NEPQLALLQI----NVMGHVNADLNN------RIAEKPRQPFTLPFPEQKSI 329
            |...:.       ::|.....|:    |::..::..:..      .:...|..|.||
Human   983 KIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTL-------- 1039

  Fly   330 FFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIAT--DLSRIPS---ELLGLPS---RV 386
             ..|..|...:.|..:::  .:|:..:.|   |.|.:.:.|  ||..|||   ::|.||.   |.
Human  1040 -CLAKYTDGNWYRGIVIE--KEPKKVFFV---DFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRC 1098

  Fly   387 FAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISYLG 451
            ..:.:.|.:|||:..
Human  1099 SLSDIPDHIPEEVVV-------------------------------------------------- 1113

  Fly   452 HKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLVVS 516
              :::|.|:..|   :..||..|:     ||.....|::            ..::.:.:   .::
Human  1114 --WFQETILDKS---LKALVVAKD-----PDGTLIIELY------------GDNIQISA---SIN 1153

  Fly   517 KQMG--HFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSC-RFLENLPVCLMRVQLQNVCNIP 578
            |::|  .::..|..|:|   ||: ..|..|.:.:...::..| .:|..    .:..:|.|...:.
Human  1154 KKLGLLSYKDRIRKKES---EVL-CSTTETLEEKNENMKLPCTEYLSK----SVGYKLPNKEILE 1210

  Fly   579 DAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAE 643
            ::..|..|::.:.|..|   :.|.|.|:|.....:|      |:..|   |:.||
Human  1211 ESYKPQINSSYKELKLL---QSLTKTNLVTQYQDSV------GNKNS---QVFPL---------- 1253

  Fly   644 VAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTK---SASHVLPIK 705
                           .|.|::::|.::       ||..:..|    |.::..|   |....||:|
Human  1254 ---------------TTEKKEEISAET-------PLKTARVE----ATLSERKIGDSCDKDLPLK 1292

  Fly   706 RFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEKILSLTSSQGACDHNV 770
               |...|:.....|.|..:.:.:.:.|... |:  ...:||.......:.|:...::
Human  1293 ---FCEFPQKTIMPGFKTTVYVSHINDLSDF-YV--QLIEDEAEISHLSERLNSVKTR------- 1344

  Fly   771 VPGYV--PNV--GELCLAIYSEDKNWYRGVCQEVKDN-MVKILFCDFGNTEYVAVRHVKPISQ-D 829
             |.|.  |.:  |::..|::.||..|||.|.:|.:.| ::.:.|.|:||   |:|.|...|.: |
Human  1345 -PEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGN---VSVVHTNKIGRLD 1405

  Fly   830 LLIAV---NVTKCYINGFDKSKN 849
            |:.|:   ....|.:.||:...|
Human  1406 LVNAILPGLCIHCSLQGFEVPDN 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009	5/34 (15%)
		TUDOR	109..225	CDD:278965	27/123 (22%)
		TUDOR	457..573	CDD:278965	21/118 (18%)
		TUDOR	718..843	CDD:278965	32/133 (24%)
		TUDOR	779..825	CDD:119391	17/46 (37%)
TDRD6	NP_001010870.1	TUDOR	<69..133	CDD:278965
		TUDOR	246..380	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..316
		TUDOR	314..360	CDD:119391
		TUDOR	483..604	CDD:278965
		TUDOR	541..585	CDD:119391
		TUDOR	770..886	CDD:278965	31/144 (22%)
		TUDOR	821..866	CDD:119391	8/45 (18%)
		TUDOR	982..1102	CDD:278965	25/133 (19%)
		TUDOR	1037..1080	CDD:119391	12/56 (21%)
		TUDOR	1301..1422	CDD:278965	32/134 (24%)
		TUDOR	1356..1401	CDD:119391	17/47 (36%)
		TUDOR	1516..1638	CDD:278965
		TUDOR	1571..>1609	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100