DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and Tdrd6

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	903	Identity:	166/903 - (18%)
Similarity:	301/903 - (33%)	Gaps:	310/903 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ENQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVA 131
            |::|. |..:::||...:|..|::|:...:.....        .|:..:|.|:::....|:....
Mouse   459 EDEVE-AAFQSQSPAEEMEAEVSLPSLRSIRLKMN--------TFYDAQVEFVKSPSEFWIRLRK 514

  Fly   132 NVEAIERMTVNMQRCMQNKKMIRMEGV----REDTLVAISVGDKVHRGHVLTVCQKKQEANVRMI 192
            :.....::|..|  |.......:::||    ..|.|..:...:..:....:|....| ..:|.::
Mouse   515 HKNTFSKLTKRM--CSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDSK-SVDVFLV 576

  Fly   193 DHGQIVATPFRDIYTIVPKMAESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKPK 257
            |.|......:.|:..::|:..:....|.:..|           ..:..||...|..|  .....|
Mouse   577 DRGNSENVDWCDVRMLLPQFRQLPILALKCTL-----------ADIWPLGKTWSQEA--TSFFKK 628

  Fly   258 MIIPLSLPLEMLQLNPEVKVIRVFKANPKHNEPQLALLQINVMGHVNADLNNRIAE--------- 313
            .::...|.:.:|.......||.:              |..:.||..|  ::..||:
Mouse   629 TVLHKELVVHVLDKQDHQYVIEI--------------LDESRMGEEN--ISKVIAQAGFAKFQEF 677

  Fly   314 --KPRQPFTLPFPEQKSIFFAATRTK-------NGYRRAFLLDHIMKPRPTYLVYE-----MDEG 364
              |.....:...|...|..|.|..:|       .|.:||      .|...|..|.|     :...
Mouse   678 ETKENIRLSAHSPGHVSGHFMAEPSKITSAKKAEGDQRA------KKDNKTLSVSEALADTVSLS 736

  Fly   365 RVSIATDLSRIPSELLGLPSRVFAAQLEDSVPE-----ELETQGAELTVKFKLDNKPP------- 417
            .:|.|.|..::.|:    ||.:....|: :.|:     |||. |:.:.||......|.
Mouse   737 NLSTAQDTEKVTSD----PSLLMLNFLK-TKPDCCGKGELEV-GSTVEVKVSHIENPGSFWCQLM 795

  Fly   418 -------------KEKLRAANAALNSKGEQICMARLITFLGQISYLGHKYWREPIV-------HD 462
                         ::..:::..:......::|:|:. |..|:        |...::       |.
Mouse   796 RNAQGFRTLMCDIEDYCKSSEPSPYEGDTRVCLAKR-TASGR--------WSRALISGAHSLEHV 851

  Fly   463 SIVFISHLVSFKEVYISTPDAKQYAEIFKRLE---YKCATITKSSDVSVGSIVLVVSKQMGHFRG 524
            .:||:.:  ..::| :||.|....:::|.::.   ::|         |:.:::..:.:....:..
Mouse   852 RVVFVDY--GDRDV-VSTKDILSVSDVFFQVRAQAFRC---------SLYNLIQPMGENPFVWDE 904

  Fly   525 EILSKDSGLFEVMNVDTGATQKVELAEIRSSCRFLENLPVCLMRVQLQNVCNIPDAAVPVNNAAI 589
            :.:...||.     :|:.....:||.                        |.:
Mouse   905 KAVQAFSGF-----IDSARQNNLELK------------------------CTV------------ 928

  Fly   590 QMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAEVAPPKAASTPS 654
               ..|.::.|....|:||                         :.||.|........|..:.|.
Mouse   929 ---FALASRHEEEWFNVVD-------------------------LLTPFQSACRFLVEKRLARPV 965

  Fly   655 QLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTKSASHVLPIKRFLFDALPKNLAPL 719
                   |.||            ||.||       ..:.|...::|.|.|
Mouse   966 -------KHQK------------PLEPS-------VQLHSYYYSTHDLKI--------------- 989

  Fly   720 GDKVNLILMNADGLPQTGYITAAYFKDEKAAKEF--------EKILSLTSSQGACDHNVVPGYVP 776
            |.:..:.:.:||. |.|.|...|  ::....::.        :.:|:|.:|      .:.|
Mouse   990 GSEELVYVTHADD-PWTFYCQLA--RNTNVLEQLSYNIMQLSKALLNLKAS------TLAP---- 1041

  Fly   777 NVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCDFGNTEYVAVRHVKPISQD----LLIAVNVT 837
              |.||||.|: |.|||||:..|.:.:  |:.|.||||| |:||.|:.||.:|    ||:.:...
Mouse  1042 --GTLCLARYT-DGNWYRGIIIEKEPS--KVFFVDFGNT-YIAVDHLLPIPRDAHDVLLLPMQAL 1100

  Fly   838 KCYING-----------------FDKSKNFAALEQFLVRKIRFLCGVKKGPEPDTRLI 878
            ||.::.                 .|||     |:..:|.|           :||.|||
Mouse  1101 KCSLSDIPHHIPEEVTAWFQETVLDKS-----LKALVVAK-----------DPDGRLI 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009
		TUDOR	109..225	CDD:278965	19/119 (16%)
		TUDOR	457..573	CDD:278965	15/125 (12%)
		TUDOR	718..843	CDD:278965	42/136 (31%)
		TUDOR	779..825	CDD:119391	24/45 (53%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315
		TUDOR	313..359	CDD:119391
		TUDOR	489..610	CDD:278965	20/142 (14%)
		TUDOR	547..591	CDD:119391	7/44 (16%)
		TUDOR	773..890	CDD:278965	19/138 (14%)
		TUDOR	826..869	CDD:119391	11/54 (20%)
		TUDOR	987..1106	CDD:278965	44/152 (29%)
		TUDOR	1042..1084	CDD:119391	24/45 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296
		TUDOR	1309..1428	CDD:278965
		TUDOR	1362..1406	CDD:119391
		TUDOR	1519..1641	CDD:278965
		TUDOR	1574..1621	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100