DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9925 and tdrd15

DIOPT Version :9

Sequence 1:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_031758847.1	Gene:	tdrd15 / 101731147	XenbaseID:	XB-GENE-6462376	Length:	1916	Species:	Xenopus tropicalis

Alignment Length:	987	Identity:	198/987 - (20%)
Similarity:	312/987 - (31%)	Gaps:	343/987 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DLSENWRKHLLPSGMEFFK-------CRVTFMENDGPIWVVHVANVEAIERMTVNMQRC------ 146
            ||:.|.  ||....:..|.       |..|..|......|...|:.||:...|:.|...
Frog   432 DLNANC--HLTNQCVPVFSPNCYRSLCDSTLPEKPSTFCVPDKASTEAVFHKTIQMDADSVHVGY 494

  Fly   147 ----------------MQNKKMIRMEGVRE------------------DTLVAISVGDK-VHRGH 176
                            :||:....||.:.|                  |...|:...|: .:|..
Frog   495 VEYVLNPSNFWIRTDELQNEFSAMMEKIAETYNPCGPTERVLKDPEPGDLCCALYYKDRHYYRAI 559

  Fly   177 VLTVCQKKQEANVRMIDHGQIVATPFRDIYTIVPK--------MAESKAFAFRVQLPTNTGVQDI 233
            |..:...|  ..|...|.|.....|..|:.|::|:        |..|.|:|:.|:   :..|:..
Frog   560 VTDILDLK--VAVYFFDFGNTETVPCYDVKTLLPEFEILPALAMCCSLAYAYPVE---DVWVKSA 619

  Fly   234 KNLTLRMLGTKTSDGAYHVHLKPKM----------------IIPLSLPLE-----MLQLNPEVKV 277
            .:...||:..|..  .:||.:|.|.                |:.:.:...     .:.|||...|
Frog   620 NDFFKRMVSGKAL--LFHVLVKHKYKYIVDARYLEDSENSDIVMMMVKAGYAEYWKVNLNPSPVV 682

  Fly   278 IRV-----FKANP--KHNEPQLALLQINVMGHVNADLNNRIAEKPRQPFTLPFPEQKSIFFAATR 335
            .::     :|.:.  |.|:.::.:.:     ||..:.|.|...:..:...||...::.:|...:.
Frog   683 TKIRSTGKYKNSKVVKQNKTRMTIAK-----HVLKNENERSRNQSPKTEVLPITFKQYLFKPGSV 742

  Fly   336 TK------NGYR----------RAFLLDHIMKPRPTY---------------------------- 356
            ..      |..|          .|..|:.|||...:|
Frog   743 VNVKCSHVNSPRDFWCQLLTETSALALESIMKDIQSYYSCCNDMYKHGQIACIVKCADSGIFYRA 807

  Fly   357 LVYEMDEGRVSI------------ATDLSRIPSELLGLPSRVFAAQLEDSV----PEELETQGAE 405
            .|:.:.|..|.|            .:||..|..:.|.|..:.|...|...:    |....|  :|
Frog   808 AVHNVTEKAVDIILVDYGYSKRALISDLREIKPQFLALEGQAFRCSLNSFLTPVRPHLSWT--SE 870

  Fly   406 LTVKFK-LDNKPPKEKLRAANAALNSKGEQ------------ICMARLITFLGQISYLGHKYWRE 457
            ....|| ..|....|.|:....||.|.|..            :|:.:.:...|..::
Frog   871 ACRDFKDFVNSSVTEDLKCTVHALFSMGTTDLFNAVSLEKRFVCVCQFLLNKGHTAF-------- 927

  Fly   458 PIVHDSIVFISHLVSF------------KEVYI----STPDAKQYAEIFKRLEYKCATITKSSDV 506
              .|.||..|: |.||            ::|||    ||  ::.|.::.:..|...|.:.:.||:
Frog   928 --SHASIPLIT-LRSFCYSDFNIKVGNLEQVYITHVYST--SRFYCQLVRNTEAIEALMKRVSDI 987

  Fly   507 ----------SVGSIVLVVSKQMGHFRGEILS--KDSGLFEVMNVDTGATQKVELAEIRSSCRFL 559
                      ....:.:|...:.|||...:..  :.|.||....||.|.:|.|...|:
Frog   988 GDQLIQTDCTKESKLCIVKYFEDGHFYRALACPIESSLLFSAFFVDFGNSQMVTKKEL------- 1045

  Fly   560 ENLPVCLMRVQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSR 624
              ||             |||.|..:.:..:|.:     |..|..|..|..|...:..|    |..
Frog  1046 --LP-------------IPDTAADLLSEPMQAI-----QFYLAGLENVVFTEEVIKWL----DEN 1086

  Fly   625 SLTTQMLPLIFTPVQEKAEVAPPKAASTPSQLPVVTHKQ-----QKVSPQSLLLLDLPP------ 678
            .|..|:..::.             |....:||.|..:|:     |||..    ||..||
Frog  1087 CLGMQLNAVVL-------------AKDCDNQLVVDLYKEKLHINQKVKE----LLGYPPSGDNIV 1134

  Fly   679 -LPPSPPE-SPFPADVTSTKSASHVL---------------PIKRFL--FDALPKNLAPLGDKVN 724
             ||....| :|......|.|....::               |..|.:  |:.|..|........|
Frog  1135 ILPQLKNEINPTSEKGISKKQTEQLMSQMLKCETPSQIDEVPTARLVSAFENLSVNQMQCNSVQN 1199

  Fly   725 LI----------------LMNADGLPQ---------TGYIT-----AAYF----KDEKA----AK 751
            |:                .:....||:         .|||:     ::::    |:|.|    |:
Frog  1200 LVHREGKVALDVITSPRTCITCSDLPECLIEPLSKDVGYISHINSPSSFYIQLSKNENAIVHLAE 1264

  Fly   752 EFEK-ILSLTS-SQGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVK-DNMVKILFCDFG 813
            |..| .||..: |...|          ..|.|..|.|.:|..:||....|:| |...::.|.|:|
Frog  1265 ELNKEPLSFQALSARDC----------KKGMLVAAEYPDDLCFYRAEILEMKEDKSFEVKFIDYG 1319

  Fly   814 NTEYVAVRHVKP 825
            ||.||:...:.|
Frog  1320 NTAYVSSLFLLP 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009
		TUDOR	109..225	CDD:278965	33/171 (19%)
		TUDOR	457..573	CDD:278965	32/143 (22%)
		TUDOR	718..843	CDD:278965	35/149 (23%)
		TUDOR	779..825	CDD:119391	17/46 (37%)
tdrd15	XP_031758847.1	Tudor_TDRD15_rpt1	33..178	CDD:410507
		Tudor_TDRD15_rpt2	264..381	CDD:410508
		Tudor_SF	485..625	CDD:413384	25/144 (17%)
		Tudor_SF	732..857	CDD:413384	20/124 (16%)
		Tudor_SF	942..1067	CDD:413384	31/153 (20%)
		Tudor_SF	1244..1349	CDD:413384	28/98 (29%)
		Tudor_TDRD15_rpt7	1462..1621	CDD:410513
		TUDOR	1670..1783	CDD:395449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100