Protein Alignment Kots and TDRD15

DIOPT Version :10

• Sequence 1: NP_650324.1
• Gene: Kots / 41702
• FlyBaseID: FBgn0038191
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001293066.1
• Gene: TDRD15 / 100129278
• HGNCID: 45037
• Length: 1934
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 187/1052 - (17%)
• Similarity: 321/1052 - (30%)
• Gaps: 413/1052 - (39%)

  Fly   116 VTFMENDGPIWVVHVANVEAIERMTVNMQR----CMQNKKMIRMEGVREDTLVAISVGDKVHRGH 176
            :.::.|....||....:....:.:..|:.:    |..::.::|..   |..|...:...|..|.:
Human   488 IAYVLNPSNFWVRTNDHRNEFQEIMKNINKFYDLCENDEMILRKP---EPGLFCCARYSKDRRFY 549

  Fly   177 VLTVCQ-KKQEANVRMIDHGQIVATPFRDIYTIVPKMAESKAFAFRVQLPTNTGVQDI------- 233
            ...:.: ...:.||..:|:|...:.||.|:..::|:..|..|.|....|.....|:|:
Human   550 RAVITEINGYKINVYFLDYGNTDSIPFFDVKILLPEFCELPALAMCCSLAHIFPVEDLWTKAAID 614

  Fly   234 --------KNLTLRMLGTKTSDGAYHVHLK----PKMIIPLSLPL-------------------- 266
                    |.:.|:::..|  |..|.|:::    .:.|..:||.|
Human   615 YFKKLVLNKAILLQVIAKK--DDKYTVNIQSVEASENIDVISLMLQAGYAEYFQVELEYFPKSVS 677

  Fly   267 EMLQLNPE-------VKVIRVFKANPK----HN----EPQLAL---LQINVMGHVNADLNNRIAE 313
            |...||.|       .|||......||    |:    |..|:|   |.:|:....|
Human   678 EYSMLNSESKNKVNIKKVISALLEGPKSKKYHSNNLVENNLSLPKSLAVNISEFKN--------- 733

  Fly   314 KPRQPFTL------PFPEQKSIFFAAT-------------------------------RTKNGYR 341
                ||||      .:|.::.||...|                               :.:|.|.
Human   734 ----PFTLSVGPESSWPYKEYIFRPGTVLEVKCSCYYGPGDFSCQLQCKSEDLKLLMEQIQNYYS 794

  Fly   342 ----------------------RAFLLDHIMKPRPTYLVYEMDEGRVSIATDLSRIPSELLGLPS 384
                                  ||.:|..:.|......|....:.||.| .||..|....|.|.|
Human   795 IHSDPYEIGQTACVAKYSGKWCRAAVLTQVSKEVDIVFVDYGYQKRVLI-EDLCAINPRFLLLES 858

  Fly   385 RVFAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISY 449
            :.|...|...:.          .|..||.:...|......|...:|:|...|:...:.
Human   859 QAFRCCLNHFIE----------PVSCKLFSWTRKAFRDLWNFISSSRGLLTCIIYALV------- 906

  Fly   450 LGHKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLV 514
                     |:|.     :||.:..::..|...||::  :..|...:..|::::..
Human   907 ---------IIHP-----NHLYNLVDLQSSFTSAKEF--LMNRGSAQYITLSETFP--------- 946

  Fly   515 VSKQMGHFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSCRF--------------------- 558
                      .:.|..|..:...|:..|:.::|.::.|.|..:|
Human   947 ----------SLFSLYSYCYSSFNIQIGSEEEVYISHIYSPQKFYCQLGRNNKDLEMIETKITES 1001

  Fly   559 --LENLP--------VCLMRVQLQNVCNIPDAAVPVNNAA-IQMLHKLCAQKELLKLNMVDATTS 612
              |:|.|        ||:.: .:::..:....|:|.:::: .|:.......|:|:..||:
Human  1002 VNLQNFPKYDSNKMRVCISK-YVEDGLSYRALAIPTDSSSEFQVYFVDFGNKQLVGENML----- 1060

  Fly   613 TVDLLFSSGDSRSLTTQMLPLIFTPVQ-------EKAEVAPPKAAST------------------ 652
                       |:::.|...|:|||:|       :..:|..|...|:
Human  1061 -----------RAISAQFPELLFTPMQAIKCFLSDLRDVDIPAEISSWFKDNFLGRSLKAIILSQ 1114

  Fly   653 -----------------PSQLPVVTH--------------KQQKVSPQSLLLLDLPPL------- 679
                             ..::.|:.|              |..|::........|...
Human  1115 ESDGQLGIELYDGSQYINEKIKVLLHAYGKRHCDQACCMEKSNKINENKRFTTSLKGKTGNNYRH 1179

  Fly   680 ----PPSPPESPFPADVT-STKSASHVLPIK----RFLFDALPKNLAPLGDKVNLILMNADGL-- 733
                .|||        || |.:....::..|    |||..::...:.|:........:| |||
Human  1180 NVINKPSP--------VTYSERKIDQLMHPKNIHARFLKPSVCYKMEPVSKNKMKTSLN-DGLKG 1235

  Fly   734 ----PQTGYITAAYFKDEKAAK----EFEKILSLTSSQGACD----------------HNVVPGY 774
                |...:|.......:|:.|    .|.:.|:.|:||...|                :..|.||
Human  1236 IKIVPGAAHILENRRVGQKSVKVVSQSFIRALNQTTSQNPYDLIRPQIKDLPQPQIYLNAKVKGY 1300

  Fly   775 VPN-----------------------------------------VGELCLAIYSEDKNWYRGVCQ 798
            |.|                                         ||:|.:|.||.|...||.|.:
Human  1301 VSNISNPANFHIQLAENESVIIRLADALNATARRLRERKSVKPLVGDLVVAEYSGDNAIYRAVIK 1365

  Fly   799 EV-KDNMVKILFCDFGNTEYVAVRHVKPISQDLLIAVNVTKCYINGFDKSKNFAALEQFLVRKIR 862
            :: ..|..::.|.|:||:                ..||.:|.|    :..:.|..:.|..:.  .
Human  1366 KILPGNSFEVEFIDYGNS----------------AIVNTSKIY----ELQREFLTVPQLGIH--A 1408

  Fly   863 FLCGVKKGPEPD 874
            ||.|||.. |||
Human  1409 FLSGVKWN-EPD 1419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kots	NP_650324.1	zf-MYND	9..44	CDD:460312
		TUDOR	110..225	CDD:425754	21/113 (19%)
		TUDOR	465..573	CDD:425754	20/138 (14%)
		TUDOR	743..843	CDD:425754	32/161 (20%)
TDRD15	NP_001293066.1	Tudor_TDRD15_rpt1	14..160	CDD:410507
		Tudor_TDRD15_rpt2	239..358	CDD:410508
		Tudor_TDRD15_rpt3	478..618	CDD:410509	24/132 (18%)
		Tudor_TDRD15_rpt4	747..868	CDD:410510	21/121 (17%)
		Tudor_TDRD15_rpt5	956..1082	CDD:410511	25/142 (18%)
		Tudor_TDRD15_rpt6	1306..1413	CDD:410512	23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1510
		Tudor_TDRD15_rpt7	1526..1678	CDD:410513
		TUDOR	1740..1852	CDD:425754