Protein Alignment Ipp and INPP1

DIOPT Version :9

• Sequence 1: NP_731872.1
• Gene: Ipp / 41701
• FlyBaseID: FBgn0016672
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_001122400.1
• Gene: INPP1 / 3628
• HGNCID: 6071
• Length: 399
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 156/400 - (39%)
• Similarity: 222/400 - (55%)
• Gaps: 44/400 - (11%)

  Fly     8 ASLLRVLINCAEKAANIARICRSNEQLLALLVQEKIGSEANERFEHDFKTLADVLIQETIKHEVG 72
            :.:||.|:..:||||||||.||..|.|..||::||...|.|::|..|||||||||:||.||..:.
Human     2 SDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKQNME 66

  Fly    73 ALFPAMKDAILGEESPNFTNQLGESVTIAVGATEEDTAACLQAVLSGHEDAASALATEVHRDVSF 137
            ..||.::..|.||||..|||..||.:|:.:.:|||:||..|..||:|::.|:.|||..||:||:|
Human    67 NKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEALARVVHQDVAF 131

  Fly   138 SSEKLG--EIAQLPDELDYGNLGIWIDPIDATAEYISGDTMFTDFPGITSTGLDCVTVLIGVYER 200
            :...|.  || .:|.::    ||||:||||:|.:||.|........||...||.|||:|||||:.
Human   132 TDPTLDSTEI-NVPQDI----LGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQCVTILIGVYDI 191

  Fly   201 DTGVPVMGVVAQPFGEKLEENV--YSSSMFWGVCLPTVRAHNCDFEARDENRRLG---------- 253
            .||||:|||:.|||..: :.|.  :....:||:.......|:.....   :||.|
Human   192 QTGVPLMGVINQPFVSR-DPNTLRWKGQCYWGLSYMGTNMHSLQLTI---SRRNGSETHTGNTGS 252

  Fly   254 ----------IFSSSEQSDI---LQRFLDLGYEFAFSAGAGHKALKVITHEVDVYLLSKGSTFKW 305
                      :.|:||:..|   |.|.  .|.....:||||:|:|.|:...||:|:.|:.:||||
Human   253 EAAFSPSFSAVISTSEKETIKAALSRV--CGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKW 315

  Fly   306 DTCAPQAILRALGGDVLDYAASVAEQKAV-----PLKYLIE-DAEADADWKRNAGGIISVRNVDV 364
            |:||..|||||:||.::|....:......     .|.|.:| :..|..|...|.||:|:.|:...
Human   316 DSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKR 380

  Fly   365 VDELLAKLAE 374
            ::..|:.|.:
Human   381 LETFLSLLVQ 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ipp	NP_731872.1	IPPase	10..371	CDD:238818	155/393 (39%)
INPP1	NP_001122400.1	IPPase	4..387	CDD:238818	155/393 (39%)
		Substrate binding. /evidence=ECO:0000250	155..158		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145832
Domainoid	1	1.000	171	1.000	Domainoid score	I3763
eggNOG	1	0.900	-	-		E1_COG1218
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1655
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3282
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49550
OrthoDB	1	1.010	-	-		D1096950at2759
OrthoFinder	1	1.000	-	-		FOG0008935
OrthoInspector	1	1.000	-	-		oto91483
orthoMCL	1	0.900	-	-		OOG6_107969
Panther	1	1.100	-	-	LDO	PTHR43028
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5414
SonicParanoid	1	1.000	-	-		X6675
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.890