DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and PRMT9

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_612373.2	Gene:	PRMT9 / 90826	HGNCID:	25099	Length:	845	Species:	Homo sapiens

Alignment Length:	311	Identity:	85/311 - (27%)
Similarity:	151/311 - (48%)	Gaps:	44/311 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FLEGKDSDYFQSYSRLET-HMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAAE 74
            |.:.|::.|..:...:|. |..||.|:.|...: :|.:|.......|.|||:|.||||||:||.:
Human   134 FSDAKENFYRVANWLVERWHFIMLNDTKRNTIY-NAAIQKAVCLGSKSVLDIGAGTGILSMFAKK 197

  Fly    75 AGASKVIAVECT-DIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGI-EKVDIIVSEWMGNALY 137
            |||..|.|.|.: .:.::|.:::..|:.|..:|::......:|:|..| |:|.::|:|.:...|:
Human   198 AGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLF 262

  Fly   138 MEAMINSVLFARDKWL----TRG--------GRILPSTGNLWLM-------------GAYD---P 174
            .|.::.|::.|.:..|    |:|        |:::|::..::.|             |..|   .
Human   263 GEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGI 327

  Fly   175 HRRTNLNFWCNV-EGIDMGCVRKPFSQEPLVEFVPIQQLLTDECF----IHSTNLAVARNQPVEF 234
            |..||:.|.... ..:|.....:|::.|.:.. ||...|...|||    :...||...::...:.
Human   328 HLPTNVKFQSPAYSSVDTEETIEPYTTEKMSR-VPGGYLALTECFEIMTVDFNNLQELKSLATKK 391

  Fly   235 QSNFQLKVMRTGIINMLVLYFDVLFPSGKSNKSVSLTTSPHSPWTHWEQTV 285
            .....:.|::.||::.::::| ||    :.:...||:||| |..|.|||.|
Human   392 PDKIGIPVIKEGILDAIMVWF-VL----QLDDEHSLSTSP-SEETCWEQAV 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	45/145 (31%)
PRMT9	NP_612373.2	TPR 1	25..58
		TPR	<39..144	CDD:223533	3/9 (33%)
		TPR 2	67..100
		TPR repeat	68..95	CDD:276809
		TPR repeat	100..130	CDD:276809
		TPR 3	101..134		85/311 (27%)
		AdoMet_MTases	148..>303	CDD:327401	47/155 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810