DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and prmt2

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001073644.2	Gene:	prmt2 / 558841	ZFINID:	ZDB-GENE-041104-1	Length:	407	Species:	Danio rerio

Alignment Length:	307	Identity:	104/307 - (33%)
Similarity:	162/307 - (52%)	Gaps:	25/307 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KDSDYFQSYSRLETHMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAA-EAGAS 78
            :|.:||.:|..|..|:.||.|..|.:.:|..|:.:....::|:|||:|||||::|||.| .|..:
Zfish    76 QDDEYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAKPA 140

  Fly    79 KVIAVECTDIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGIEKVDIIVSEWMGNALYMEAMIN 143
            .|.|||.:.:|:..||:::.|..:.||.|.:...|.:.||   .|||::|||||||.|..|.|:.
Zfish   141 GVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLP---TKVDVLVSEWMGNCLLFEYMLE 202

  Fly   144 SVLFARDKWLTRGGRILPSTGNLWLM--GAYDPHRRTNLNFWCNVEGID----MGCVRKPFSQEP 202
            |||.|||:||.:||.:.||:..|.::  .|:..:|: .:.||.|..|::    ....:|.|..:|
Zfish   203 SVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQ-KVEFWENPYGLNFSYLQSLAQKEFLSKP 266

  Fly   203 LVEFVPIQQLLTDECFIHSTNLAVARNQPVEFQ--------SNFQLKVMRTGIINMLVLYFDVLF 259
            ...    ..|..::|.  ||...|.....|..|        ..|...|.::|:.:...::|...|
Zfish   267 KFS----HHLQPEDCL--STPADVITLDMVTIQVSDLERLKGEFTFTVEKSGMFHGFTVWFSAHF 325

  Fly   260 PSGKSNKSVSLTTSPHSPWTHWEQTVLHLDEPLYVRIRDRVRGVLAM 306
            .|.:...|:.|.|.|:|..|||:||:..||.|:.|...|.:.|.:.:
Zfish   326 QSLEDGPSIELNTGPYSEITHWKQTLFMLDAPVSVEEGDIIAGSIRL 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	58/132 (44%)
prmt2	NP_001073644.2	SH3_PRMT2	14..66	CDD:212740
		PRMT5	<118..381	CDD:282971	91/265 (34%)
		AdoMet_MTases	119..216	CDD:100107	48/99 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820