DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and PRMT6

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_060607.2	Gene:	PRMT6 / 55170	HGNCID:	18241	Length:	375	Species:	Homo sapiens

Alignment Length:	347	Identity:	124/347 - (35%)
Similarity:	184/347 - (53%)	Gaps:	45/347 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KDSDYFQSYSRLETHMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAAEAGASK 79
            :|..|::.||.:..|..|:.|.||..|:|..|:::....:.|.|||||.||||||:|.|:|||.:
Human    43 RDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARR 107

  Fly    80 VIAVECTDIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGIEKVDIIVSEWMGNALYMEAMINS 144
            |.|||.:.|...|.|::|.|..|:.|.|:.|.||.||||   |:||.|||||||..|..|:|::|
Human   108 VYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELP---EQVDAIVSEWMGYGLLHESMLSS 169

  Fly   145 VLFARDKWLTRGGRILPSTGNLWLMGAYDPHRRTNLNFWCNVE---GIDMGCVRKPFSQEPLV-- 204
            ||.||.|||..||.:||::..|::....|......|.||..|:   |:||.|: :.|:...|:
Human   170 VLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCL-EGFATRCLMGH 233

  Fly   205 -EFVPIQQLLTDECFIHSTNLAVARNQPVEFQSNFQLKVMRTGI--------------------- 247
             |.| :|.|..::        .:||  |..|.   ||::.|.|:
Human   234 SEIV-VQGLSGED--------VLAR--PQRFA---QLELSRAGLEQELEAGVGGRFRCSCYGSAP 284

  Fly   248 INMLVLYFDVLFPSGKSNKSVSLTTSPHSPWTHWEQTVLHLDEPLYVRIRDRVRGVLAMTPTGQD 312
            ::...::|.|.||.|:|.|.:.|:|||..|.|||:|.:|:|:||:.|.....|.|.:.:.|:..:
Human   285 MHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDN 349

  Fly   313 GRGMNFDLHISFRGERTRVESF 334
            .|.:...|......:..:.:.|
Human   350 PRRLRVLLRYKVGDQEEKTKDF 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	67/131 (51%)
PRMT6	NP_060607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
PRMT6	NP_060607.2	AdoMet_MTases	67..>200	CDD:418430	66/135 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1503
OMA	1	1.010	-	-		QHG54098
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.780