DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and Prmt8

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_958759.2	Gene:	Prmt8 / 381813	MGIID:	3043083	Length:	394	Species:	Mus musculus

Alignment Length:	310	Identity:	128/310 - (41%)
Similarity:	206/310 - (66%)	Gaps:	5/310 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YFQSYSRLETHMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAAEAGASKVIAV 83
            ||.||:....|..||:|.||...:|:::..:..:|:||:|||||.||||||:|||:|||.||..:
Mouse    76 YFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGI 140

  Fly    84 ECTDIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGIEKVDIIVSEWMGNALYMEAMINSVLFA 148
            ||:.|:|.:|:||:.|..:||:.:.||.||:||||  :||||||:|||||..|:.|:|:|:|:||
Mouse   141 ECSSISDYSEKIIKANHLDNVITIFKGKVEEVELP--VEKVDIIISEWMGYCLFYESMLNTVIFA 203

  Fly   149 RDKWLTRGGRILPSTGNLWLMGAYD-PHRRTNLNFWCNVEGIDMGCVRKPFSQEPLVEFVPIQQL 212
            |||||..||.:.|....|:::...| .::...:::|.||.|.||.|:|....:||||:.|..:|:
Mouse   204 RDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQV 268

  Fly   213 LTDECFIHSTNLAVARNQPVEFQSNFQLKVMRTGIINMLVLYFDVLFPSGKSNKSVSLTTSPHSP 277
            :|:.|.|...::...:.:.:.|.|.|.|::.|...::.||.||::.|.  |.:|.:..:|:|.:|
Mouse   269 VTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFT--KCHKKMGFSTAPDAP 331

  Fly   278 WTHWEQTVLHLDEPLYVRIRDRVRGVLAMTPTGQDGRGMNFDLHISFRGE 327
            :|||:|||.:|::.|.||..:.:.|.::|.|..::.|.::|.:.:.|:|:
Mouse   332 YTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQ 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	72/131 (55%)
Prmt8	NP_958759.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..40
		SH3-binding 1. /evidence=ECO:0000250\|UniProtKB:Q9NR22	29..42
		SH3-binding 2. /evidence=ECO:0000250\|UniProtKB:Q9NR22	53..58
		AdoMet_MTases	115..215	CDD:100107	62/101 (61%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q9NR22	119..122		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54098
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890