DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and PRMT2

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001526.2	Gene:	PRMT2 / 3275	HGNCID:	5186	Length:	433	Species:	Homo sapiens

Alignment Length:	305	Identity:	102/305 - (33%)
Similarity:	159/305 - (52%)	Gaps:	14/305 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KDSDYFQSYSRLETHMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAAE-AGAS 78
            :|.:||.||..|:.|:.||.|..|...:...|:|:.....||::|||||||||:|||.|. |...
Human    98 QDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPR 162

  Fly    79 KVIAVECTDIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGIEKVDIIVSEWMGNALYMEAMIN 143
            .|.|||.:::|....:::..|...:::.|.:..||.|.||   ||||::||||||..|..|.||.
Human   163 AVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVVLP---EKVDVLVSEWMGTCLLFEFMIE 224

  Fly   144 SVLFARDKWLTRGGRILPSTGNLWLMG-AYDPHRRTNLNFWCNVEGIDMG-----CVRKPFSQEP 202
            |:|:|||.||...|.|.|:...|.|:. :.|...|:.:.||.|....::.     .|::.||:..
Human   225 SILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPK 289

  Fly   203 LVEFVPIQQLLTDECFIHSTNLAVARNQPVE-FQSNFQLKVMRTGIINMLVLYFDVLFPSGKSNK 266
            ....:..:..|::.|.|...::...:...:| .:...:..:.:.|.::....:|.|.|.|.:..:
Human   290 YNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQ 354

  Fly   267 SVS-LTTSPHSPWTHWEQTVLHLDEPLYVRIRDRVRG--VLAMTP 308
            ... |:|.|..|.|||:||:..:|:|:.|...|.|.|  ||...|
Human   355 PPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	58/132 (44%)
PRMT2	NP_001526.2	Interaction with ESR1	1..277		72/181 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3_PRMT2	34..86	CDD:212740
		Interaction with RB1. /evidence=ECO:0000250	83..207		44/111 (40%)
		AdoMet_MTases	110..>169	CDD:302624	26/58 (45%)
		Interaction with ESR1	133..275		59/144 (41%)
		AdoMet_MTases	141..241	CDD:100107	48/102 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920