DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art6 and PRMT3

DIOPT Version :9

Sequence 1:	NP_650322.1	Gene:	Art6 / 41699	FlyBaseID:	FBgn0038189	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_005779.1	Gene:	PRMT3 / 10196	HGNCID:	30163	Length:	531	Species:	Homo sapiens

Alignment Length:	317	Identity:	121/317 - (38%)
Similarity:	197/317 - (62%)	Gaps:	14/317 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EGKDSDYFQSYSRLETHMNMLRDSVRMQAFRDAIVQDGGLFQDKIVLDVGCGTGILSLFAAEAGA 77
            |.:|..||.||.....|..||:|.:|.:::||.|.|:..:|:||:||||||||||||:|||:|||
Human   214 EDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGA 278

  Fly    78 SKVIAVECTDIADIAEEIIRDNQKENVVKVVKGLVEQVELPDGIEKVDIIVSEWMGNALYMEAMI 142
            .||:.|:.::|...|.:|||.|:.|:.:.::||.:|:|.||  :||||:|:|||||..|..|:|:
Human   279 KKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLP--VEKVDVIISEWMGYFLLFESML 341

  Fly   143 NSVLFARDKWLTRGGRILPSTGNLWLMGAYDPHRRTN-LNFWCNVEGIDMGCVRKPFSQEPLVEF 206
            :|||:|::|:|.:||.:.|....:.|:...|.::..: :.||.:|.|..|.|::|....|.:||.
Human   342 DSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEV 406

  Fly   207 VPIQQLLTDECFI-----HSTNLAVARNQPVEFQSNFQLKVMRTGIINMLVLYFDVLFPSGKSNK 266
            :..:.|:::.|.|     |:|:::     .:||.|:|.||:.||.:...:..|||:.|.....|:
Human   407 LDPKTLISEPCGIKHIDCHTTSIS-----DLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNR 466

  Fly   267 SVSLTTSPHSPWTHWEQTVLHLDEPLYVRIRDRVRGVLAMTPTGQDGRGMNFDLHIS 323
             |..:|.|.|..|||:|||..|::|..|:..:.::|.:.:....:|.|.:...|.::
Human   467 -VVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLN 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art6	NP_650322.1	AdoMet_MTases	29..>161	CDD:302624	67/131 (51%)
PRMT3	NP_005779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
PRMT3	NP_005779.1	AdoMet_MTases	259..359	CDD:100107	55/101 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148158
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D432852at33208
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750