Protein Alignment ems and NANOG

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_079141.2
• Gene: NANOG / 79923
• HGNCID: 20857
• Length: 305
• Species: Homo sapiens
• Alignment Length: 210
• Identity: 54/210 - (25%)
• Similarity: 75/210 - (35%)
• Gaps: 72/210 - (34%)

  Fly   277 PPMPQGQP--GLPDIKALPPYINAPPELPPQHN-PHLIAAAQFQMAAALQAGHVLGPAAAAAAAA 338
            |..||..|  ...|.|...|   .|....|:.| |.|      ||::|..
Human     5 PACPQSLPCFEASDCKESSP---MPVICGPEENYPSL------QMSSAEM--------------- 45

  Fly   339 GLPPHAAQFMPNPG----MARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKP----------- 388
               ||.....|.|.    :.:||                   |.|...|..::|
Human    46 ---PHTETVSPLPSSMDLLIQDS-------------------PDSSTSPKGKQPTSAEKSVAKKE 88

  Fly   389 -------KRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRM 446
                   ::.||.||.:||..|...|:..:|:...:.:.|:..||||..|||.||||:|.|.||.
Human    89 DKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRW 153

  Fly   447 QQED-EKGGEGGSQR 460
            |:.: .|...|.:|:
Human   154 QKNNWPKNSNGVTQK 168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	23/55 (42%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		25/136 (18%)
		COG5576	74..191	CDD:227863	30/95 (32%)
		Homeodomain	97..152	CDD:459649	23/54 (43%)
		Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768	122..151		14/28 (50%)
		8 X repeats starting with a Trp in each unit	196..240
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305