Protein Alignment ems and En1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001385634.1
• Gene: En1 / 685360
• RGDID: 1595088
• Length: 409
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 128/505 - (25%)
• Similarity: 180/505 - (35%)
• Gaps: 155/505 - (30%)

  Fly     8 VPTAAAAVMMPTPKQKIGFSIESIVG-NDVSTAGGNSTPDLSGPQSPPPGERNVPGSPPQTPPAT 71
            |..|||.|....|.   |.|:....| :..|.:.|:|.|  ..||..||.    |.:.|..||
  Rat    19 VAAAAAVVAAAAPG---GLSLSLSPGASGSSGSDGDSVP--VSPQPAPPS----PPAAPCLPP-- 72

  Fly    72 LTLIPGSPPHHLMAPPAHGLPYPHPHAQQQHLQAP--HPHPHLSPAQQHVLHQHLLMQQQHP--G 132
            |...|..|||....||.     |.|....|||.||  .|.|   .||.|......:.....|  |
  Rat    73 LAHHPHLPPHPPPPPPP-----PPPPPPPQHLAAPAHQPQP---AAQLHRTTNFFIDNILRPDFG 129

  Fly   133 TPKSHQDIQELLQRLHHNAAMASGLSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAENPAQR 197
            ..|.    |.|.|.|..:||...|.:...:|             ::|:||......:
  Rat   130 CKKE----QPLPQLLVASAAAGGGAAGGGSR-------------VERDRSQTGAGRD-------- 169

  Fly   198 IQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMP 262
                  |..|:..::|..:|    |:.:|.|       ...||:..:||.....||.....|...
  Rat   170 ------PVHSLGTRASGAAS----LLCAPDA-------NCGPPDGSQPATAVGAGASKAGNPAAA 217

  Fly   263 PAGLV---------------RPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIA 312
            .|...               :|...| ||.....|.||....|.            |:|||.::
  Rat   218 AAAAAAAAAAAVAAAAAAASKPSDSG-GGSGGSAGSPGAQGAKF------------PEHNPAIL- 268

  Fly   313 AAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRF- 376
                          ::|.|..                .|.:..||.|...|    ...::..|:
  Rat   269 --------------LMGSANG----------------GPVVKTDSQQPLVW----PAWVYCTRYS 299

  Fly   377 --PGSFLVPPFRK---------PKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSET 430
              |.|  .|..||         .||.||||:..||.:|:..|::|:|:....|:.|||.|:|:|:
  Rat   300 DRPSS--GPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNES 362

  Fly   431 QVKVWFQNRRTKHKRMQQEDEKGGEGGSQRNM-------HNGSGDEDDDE 473
            |:|:||||:|.|.|:     ..|.:.|...::       |:.:..:|.||
  Rat   363 QIKIWFQNKRAKIKK-----ATGIKNGLALHLMAQGLYNHSTTTVQDKDE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/55 (49%)
En1	NP_001385634.1	Homeodomain	322..377	CDD:459649	26/54 (48%)
		Engrail_1_C_sig	378..408	CDD:431338	6/30 (20%)