Protein Alignment ems and ALX4

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_068745.2
• Gene: ALX4 / 60529
• HGNCID: 450
• Length: 411
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 78/310 - (25%)
• Similarity: 106/310 - (34%)
• Gaps: 92/310 - (29%)

  Fly   151 AAMASGLSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAENPAQRIQP-PHTPPKSVSPQSSQ 214
            ||.|.|....::|......|..:|..|:....        |.....:.|| |.||.....||
Human    51 AAKAQGFGDAKSRARYGAGQQDLATPLESGAG--------ARGSFNKFQPQPSTPQPQPPPQ--- 104

  Fly   215 PSSSPTLLISSPHATPPQQQQQQPPPNYP-KPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPP 278
                            ||.|||||.|..| :|.:....||..     .||.|.::
Human   105 ----------------PQPQQQQPQPQPPAQPHLYLQRGACK-----TPPDGSLK---------- 138

  Fly   279 MPQGQPGLPDIKALPPYIN----APPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAG 339
            :.:|..|......:|.|..    ..|||||..:   .........:..:|| |.||...|::...
Human   139 LQEGSSGHSAALQVPCYAKESSLGEPELPPDSD---TVGMDSSYLSVKEAG-VKGPQDRASSDLP 199

  Fly   340 LPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLE 404
            .|...|....|.|                                  |.:|.||.|:..||.:||
Human   200 SPLEKADSESNKG----------------------------------KKRRNRTTFTSYQLEELE 230

  Fly   405 HAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKR------MQQ 448
            ..|:...|.....|:.||...:|:|.:|:|||||||.|.::      |||
Human   231 KVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQ 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	24/55 (44%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..145		25/111 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..219		12/69 (17%)
		Homeodomain	215..271	CDD:459649	24/55 (44%)
		OAR	387..405	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	391..404