Protein Alignment ems and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_038962557.1
• Gene: Nkx2-4 / 366213
• RGDID: 1304985
• Length: 353
• Species: Rattus norvegicus
• Alignment Length: 374
• Identity: 101/374 - (27%)
• Similarity: 127/374 - (33%)
• Gaps: 137/374 - (36%)

  Fly   198 IQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMP 262
            :.|.||.|.|||.            |.||           ....|.|     .||    :|.|.|
  Rat     3 LSPKHTTPFSVSD------------ILSP-----------IEETYKK-----FGG----VMDGAP 35

  Fly   263 PAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHV 327
            | ||..|.     |....:..|..|..:|.......||.....||    |||....|||
  Rat    36 P-GLGAPL-----GAAAYRAPPTGPSSQAAAVAGMQPPHAMAGHN----AAAAAAAAAA------ 84

  Fly   328 LGPAAAAAAAAGLPPHAAQFMPNPGMARDSY-----------QLYP-------------WLLS-- 366
               ||||||...:||..:||   |..|..||           ..|.             |..:
  Rat    85 ---AAAAAATYHMPPGVSQF---PHSAMGSYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANT 143

  Fly   367 --RHGRIFPHRFPG--------------------SFLVP-----PFRKPKRIRTAFSPSQLLKLE 404
              |:..|  .||.|                    ..|.|     |.||.   |..||.:|:.:||
  Rat   144 DPRYSSI--SRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAPRRKR---RVLFSQAQVYELE 203

  Fly   405 HAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRM------QQEDEKGGEG------- 456
            ..|:..:|:...||:.||..::|:.||||:||||.|.|.||.      ||..::||.|
  Rat   204 RRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPP 268

  Fly   457 GSQRNM------------HNGSGDEDDDELIDMEMDECPSDEEHELDAS 493
            .|.|.:            .||:|.....:.........|:.|..||.:|
  Rat   269 PSPRRVAVPVLVKDGKPCQNGAGTPTPGQGGQQPQAPTPASELEELSSS 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	23/55 (42%)
Nkx2-4	XP_038962557.1	Homeodomain	188..244	CDD:459649	25/58 (43%)