Protein Alignment ems and PDX1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 71/227 - (31%)
• Similarity: 104/227 - (45%)
• Gaps: 40/227 - (17%)

  Fly   235 QQQPPPNY--PKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYIN 297
            |:.|.|.:  ..||.::.|     ..|..||.   .|||...|.  :.||.|  |||
Human    21 QRGPAPEFSASPPACLYMG-----RQPPPPPP---HPFPGALGA--LEQGSP--PDI-------- 65

  Fly   298 APPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQL-- 360
            :|.|:||..:...:|.....:.|.|...|         ..||..|..|:    ||:..:..::
Human    66 SPYEVPPLADDPAVAHLHHHLPAQLALPH---------PPAGPFPEGAE----PGVLEEPNRVQL 117

  Fly   361 -YPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQN 424
             :||:.|.....:..::.|........:.||.|||::.:|||:||..|..|:|:....|..||..
Human   118 PFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVM 182

  Fly   425 LNLSETQVKVWFQNRRTKHKRMQQEDEKGGEG 456
            |||:|..:|:||||||.|.|:  :||:|.|.|
Human   183 LNLTERHIKIWFQNRRMKWKK--EEDKKRGGG 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	28/55 (51%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		22/71 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		17/56 (30%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeodomain	147..203	CDD:459649	28/55 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		6/14 (43%)