DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ems and NOTO

DIOPT Version :9

Sequence 1:	NP_731868.1	Gene:	ems / 41697	FlyBaseID:	FBgn0000576	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001127934.1	Gene:	NOTO / 344022	HGNCID:	31839	Length:	251	Species:	Homo sapiens

Alignment Length:	236	Identity:	71/236 - (30%)
Similarity:	94/236 - (39%)	Gaps:	51/236 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PKPAMMHPGGAGPMMMPG---MPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPP 304
            |.|   .|.|:.|....|   .||.....|.|..|.||..|:. ||..:.......|.|.|:
Human     2 PSP---RPRGSPPPAPSGSRVRPPRSGRSPAPRSPTGPNTPRA-PGRFESPFSVEAILARPD--- 59

  Fly   305 QHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLP--------PH--AAQFMPNPGMARDSYQ 359
               |...||:|...:|.:..  ....||:..|..|||        |.  :..|.|.||
Human    60 ---PCAPAASQPSGSACVHP--AFWTAASLCATGGLPWACPTSWLPAYLSVGFYPVPG------- 112

  Fly   360 LYPWLLSRHGRI-----------------FPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAF 407
              |.:....|.:                 ||...|...|....|:.||:||.|:..||.:||..|
Human   113 --PRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTEDLQDTERQQKRVRTMFNLEQLEELEKVF 175

  Fly   408 ESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQ 448
            .....:||.:|..||..|.|:|.||:|||||||.|:::.|:
Human   176 AKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQK 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	26/51 (51%)
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		16/48 (33%)
		Homeobox	160..211	CDD:278475	25/50 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810