Protein Alignment ems and HOXA13

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 82/358 - (22%)
• Similarity: 128/358 - (35%)
• Gaps: 97/358 - (27%)

  Fly   149 HNAAMASG--LSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAENPAQRIQPPHTPPKSVSPQ 211
            |.||.|:|  .|......:..........:|....:|..|....|.:.|    |...||.:.:..
Human    60 HPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSA----PGEAPPSAAAAA 120

  Fly   212 SSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGG 276
            ::..:::.....:|....             |.||    |.||........|.........||..
Human   121 AAAAAAAAAAAAASSSGG-------------PGPA----GPAGAEAAKQCSPCSAAAQSSSGPAA 168

  Fly   277 PPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQA-----GHVLGPAAAAAA 336
            .|......|......:.|:.||           :.:.||...|||..|     ....||||...:
Human   169 LPYGYFGSGYYPCARMGPHPNA-----------IKSCAQPASAAAAAAFADKYMDTAGPAAEEFS 222

  Fly   337 -------------AAGLPPHAAQFMP------------NPGMAR--------DSYQLYPWLLSR- 367
                         ||| |.|..|.||            .||.:|        :|||  ||.|..
Human   223 SRAKEFAFYHQGYAAG-PYHHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQ--PWALPNG 284

  Fly   368 -HGRIF--------PHRFPGSFLVP----------PFRKPKRIRTAFSPSQLLKLEHAFESNQYV 413
             :|:::        ||.:..:  :|          .:|:.::.|..::..||.:||..:.:|:::
Human   285 WNGQMYCPKEQAQPPHLWKST--LPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFI 347

  Fly   414 VGAERKALAQNLNLSETQVKVWFQNRRTKHKRM 446
            ...:|:.::...||||.||.:||||||.|.|::
Human   348 TKDKRRRISATTNLSERQVTIWFQNRRVKEKKV 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	20/55 (36%)
HOXA13	NP_000513.2	HoxA13_N	85..224	CDD:463521	33/170 (19%)
		Homeodomain	323..379	CDD:459649	20/55 (36%)