Protein Alignment ems and HOXA11

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 67/296 - (22%)
• Similarity: 106/296 - (35%)
• Gaps: 74/296 - (25%)

  Fly   199 QPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPN----YPKPAMMH------PGGA 253
            |.|.:.|.:.|..|:.|...|...::..........:..|..|    |....::|      |..|
Human    36 QTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAA 100

  Fly   254 GPMMMPG------------MPPAGLVRPF--PMGPGGPPMPQG-------QPGLPDIKALPPYIN 297
            |   :||            .|...:...|  .:|..| .:||.       ..|.|:..|...|
Human   101 G---VPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNG-VLPQAFDQFFETAYGTPENLASSDY-- 159

  Fly   298 APPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYP 362
             |.:...:..|....|..               |||||||.|.|..::......|..|::.....
Human   160 -PGDKSAEKGPPAATATS---------------AAAAAAATGAPATSSSDSGGGGGCRETAAAAE 208

  Fly   363 WLLSRHGRIFPHRFPGSFLVPPF--------------RKPKRIRTAFSPSQLLKLEHAFESNQYV 413
            ....|       |.|.|...|..              ::.::.|..::..|:.:||..|..:.|:
Human   209 EKERR-------RRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYI 266

  Fly   414 VGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQE 449
            ...:|..|::.|||::.|||:||||||.|.|::.::
Human   267 NKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRD 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	21/55 (38%)
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	24/120 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		21/116 (18%)
		Homeodomain	242..298	CDD:459649	21/55 (38%)