Protein Alignment ems and HOXA10

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 107/526 - (20%)
• Similarity: 158/526 - (30%)
• Gaps: 220/526 - (41%)

  Fly     6 PPVPTAAAAVMMPTPKQKIGFSIESIVGNDVSTAGGNSTPDLSGPQSPPPGERNVPGSPPQTPPA 70
            |..||..:....|...   .|.::|::.:....|||..    .|......|.....|.
Human    12 PNYPTTMSCSESPAAN---SFLVDSLISSGRGEAGGGG----GGAGGGGGGGYYAHGG------- 62

  Fly    71 TLTLIPGSPPHHLMAPPAHGLPYPHPHAQQQHLQAPHPHPHLSPAQQHVLHQHLLMQQQHPGT-- 133
                        :..|||..|||        .||:....|.|...:.         :...||:
Human    63 ------------VYLPPAADLPY--------GLQSCGLFPTLGGKRN---------EAASPGSGG 98

  Fly   134 ------PKSHQDIQELLQRLHHNAAMASGLSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAE 192
                  |.:|                ..|.||:...|.                  ||.:.
Human    99 GGGGLGPGAH----------------GYGPSPIDLWLD------------------APRSC---- 125

  Fly   193 NPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPA----------- 246
                |::||..||                        ||.|||..|||..|:||
Human   126 ----RMEPPDGPP------------------------PPPQQQPPPPPQPPQPAPQATSCSFAQN 162

  Fly   247 --------MMHPGGAGPMMMPGMPPAGLVRPFPMGP----------GGPPMP------------- 280
                    :.......|.:   ...|..:.|||.||          .|.|:|
Human   163 IKEESSYCLYDSADKCPKV---SATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAK 224

  Fly   281 ---QGQPGLPDIKALPPYINAPP----ELPPQHNPHLIAAAQFQMA---------AALQAGHVLG 329
               .|..|...:.| .|:...||    :|||........||:.:.|         |....|...|
Human   225 GYGSGGGGAQQLGA-GPFPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQG 288

  Fly   330 PAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYP---------------WLLSRHGRIFPHRFPGS 379
            ...|.|:::.    |.:..|.|.   :|.:..|               ||.::.||
Human   289 DEEAHASSSA----AEELSPAPS---ESSKASPEKDSLGNSKGENAANWLTAKSGR--------- 337

  Fly   380 FLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHK 444
                      :.|..::..|.|:||..|..|.|:....|..::::::|::.|||:||||||.|.|
Human   338 ----------KKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLK 392

  Fly   445 RMQQED 450
            :|.:|:
Human   393 KMNREN 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	20/55 (36%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158		26/143 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339		26/144 (18%)
		Homeodomain	337..393	CDD:459649	21/74 (28%)