Protein Alignment ems and HOXA4

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_002132.3
• Gene: HOXA4 / 3201
• HGNCID: 5105
• Length: 320
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 85/321 - (26%)
• Similarity: 118/321 - (36%)
• Gaps: 94/321 - (29%)

  Fly   128 QQHPGTPKSHQDIQELLQRLHHNAAMASGLSPLQTRLSPETEQPQMAVSLKRERSPAPPAMEQAE 192
            ||.|..|..|..:|:  .:|.|   ...|..|..:..:|.|           .|.||
Human    43 QQPPAPPTQHLPLQQ--PQLPH---AGGGREPTASYYAPRT-----------AREPA-------- 83

  Fly   193 NPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMM 257
            .||..:.|.|....:..|...:..:||        ..||  |.:|||.....||  |...|..::
Human    84 YPAAALYPAHGAADTAYPYGYRGGASP--------GRPP--QPEQPPAQAKGPA--HGLHASHVL 136

  Fly   258 MPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAAL 322
            .|.:||       |:.|               :|:||                  ||..:..||
Human   137 QPQLPP-------PLQP---------------RAVPP------------------AAPRRCEAA- 160

  Fly   323 QAGHVLGPAAAAAAAAGLPPHAAQFMPNP---GMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPP 384
                   ||.....|.|..|.....:.:.   |:......:|||:...|.......:.|.
Human   161 -------PATPGVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGG----- 213

  Fly   385 FRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKR 445
              :|||.|||::..|:|:||..|..|:|:....|..:|..|.|||.|||:||||||.|.|:
Human   214 --EPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKK 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	28/55 (51%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..77		10/38 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..168		27/126 (21%)
		Antp-type hexapeptide	194..199		3/4 (75%)
		Homeodomain	216..272	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..320		85/321 (26%)