Protein Alignment ems and HOXA2

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_006726.1
• Gene: HOXA2 / 3199
• HGNCID: 5103
• Length: 376
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 83/273 - (30%)
• Similarity: 114/273 - (41%)
• Gaps: 73/273 - (26%)

  Fly   204 PPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQP---PPNYPKPAMMHPGGAGPMMMPGMPPAG 265
            ||.:   .:.|.||..|..:|.....||..:|..|   |.::|:    |  |||     |.|
Human    26 PPVA---DTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPR----H--GAG-----GRP--- 73

  Fly   266 LVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGP 330
              :|.|.|..|.|:|.|        ||     .|||.|           ..:...|.:...:|..
Human    74 --KPSPAGSRGSPVPAG--------AL-----QPPEYP-----------WMKEKKAAKKTALLPA 112

  Fly   331 AAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAF 395
            |||||.||...|.......:..:|..|                  ..||         :|:|||:
Human   113 AAAAATAAATGPACLSHKESLEIADGS------------------GGGS---------RRLRTAY 150

  Fly   396 SPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQR 460
            :.:|||:||..|..|:|:....|..:|..|:|:|.||||||||||.||||..|..|.....|..:
Human   151 TNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCK 215

  Fly   461 NMHNGSGDEDDDE 473
            ::.:....|:|:|
Human   216 SLEDSEKVEEDEE 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	29/55 (53%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..93		22/79 (28%)
		Antp-type hexapeptide	94..99		2/15 (13%)
		Homeodomain	144..200	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..229		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..279