Protein Alignment ems and HMX1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 76/240 - (31%)
• Similarity: 94/240 - (39%)
• Gaps: 71/240 - (29%)

  Fly   246 AMMHPG--GAGPMMMPGMPPAGLVRPFPMGPGGP----PMPQGQPG---LPDIKALPPYINAPPE 301
            |::.||  |.||...||..|     ||.:|.||.    |...|..|   .||...     ...||
Human    85 ALLGPGALGLGPRPPPGPGP-----PFALGCGGAARWYPRAHGGYGGGLSPDTSD-----RDSPE 139

  Fly   302 L-----------PPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLP--PHAAQFMPNPGM 353
            .           |....|..:.....::||.       ||||....|:.|.  |.||      |.
Human   140 TGEEMGRAEGAWPRGPGPGAVQREAAELAAR-------GPAAGTEEASELAEVPAAA------GE 191

  Fly   354 ARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAER 418
            .|                      |...|...|| |:.||.||.||:.:||..|:..:|:..|||
Human   192 TR----------------------GGVGVGGGRK-KKTRTVFSRSQVFQLESTFDLKRYLSSAER 233

  Fly   419 KALAQNLNLSETQVKVWFQNRRTKHKRM---QQEDEKGGEGGSQR 460
            ..||.:|.|:|||||:||||||.|.||.   :.|.......|:||
Human   234 AGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASLSPPGAQR 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	30/55 (55%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		38/162 (23%)
		Homeodomain	206..260	CDD:459649	29/53 (55%)
		HMX family specific domain 1	263..273		1/9 (11%)
		HMX family specific domain 2	276..289		2/3 (67%)