Protein Alignment ems and Pdx1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 283
• Identity: 79/283 - (27%)
• Similarity: 115/283 - (40%)
• Gaps: 54/283 - (19%)

  Fly   212 SSQPSSSPTLLISSPHATPPQQQQQQPPPNYP--KPAMMHPGGAGPMMMPGMPPAGLVRPFPMGP 274
            |.:...:.|.|...|.|.     |:.|.|.:.  .||.::.|...|      ||     |.|...
  Rat     3 SEEQYYAATQLYKDPCAF-----QRGPVPEFSANPPACLYMGRQPP------PP-----PPPQFA 51

  Fly   275 GG-PPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGH-VLGPAAAAAAA 337
            |. ..:.||.|  |||        :|.|:||..:....|.....:.|.|...| ..||.......
  Rat    52 GSLGTLEQGSP--PDI--------SPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTET 106

  Fly   338 AGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLK 402
            .||...:...:|           :||:.|.....:..::.|........:.||.|||::.:|||:
  Rat   107 GGLEEPSRVHLP-----------FPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLE 160

  Fly   403 LEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQRNMHNGSG 467
            ||..|..|:|:....|..||..|||:|..:|:||||||.|.|:  :||:|...|.:.    .|.|
  Rat   161 LEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKK--EEDKKRSSGTTS----GGGG 219

  Fly   468 DEDDDELIDMEMDECPSDEEHEL 490
            .|:.::       :|......||
  Rat   220 GEEPEQ-------DCAVTSGEEL 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	28/55 (51%)
Pdx1	NP_074043.4	Transactivation domain	13..73		24/85 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		17/65 (26%)
		Antp-type hexapeptide	118..123		3/15 (20%)
		Homeodomain	147..203	CDD:459649	28/55 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		11/48 (23%)