Protein Alignment ems and GBX2

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 94/324 - (29%)
• Similarity: 126/324 - (38%)
• Gaps: 75/324 - (23%)

  Fly   204 PPKSVSPQ----SSQPSSSPTLLISSPHATP------------PQQQQQQPPPNYPKPAMMHPGG 252
            ||..:..|    ||...|..:|:.|.|..:|            |.:....|||..|.||:  |..
Human     6 PPSLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPPPPAL--PQA 68

  Fly   253 AGPMMMPGMPPAGLVRPFPMGPGG--PPMPQGQPGLPDIKA-LPPYINAPPE---------LPPQ 305
            |   :.|.:|||......|..|.|  ..:.||......:.| ||...:|.|:         ..||
Human    69 A---LQPALPPAHPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSASPQHQEAAAARKFAPQ 130

  Fly   306 HNPHLIAAAQFQMAAALQA------------GHVLGPAAA-------AAAAAGLPPHAAQFMPNP 351
            ..|   ....|..|.||||            |.:|..:||       ..|..|.....::...:|
Human   131 PLP---GGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDP 192

  Fly   352 GMARDSYQL-----YPWLLSRHGRIFPHR--FPGSFL--VPPFR----------KPKRIRTAFSP 397
            ....:|:.|     |....:..|:. .|:  .||..|  .||..          |.:|.||||:.
Human   193 KGKEESFSLESDVDYSSDDNLTGQA-AHKEEDPGHALEETPPSSGAAGSTTSTGKNRRRRTAFTS 256

  Fly   398 SQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQRN 461
            .|||:||..|...:|:...||..:|..|.|||.|||:||||||.|.||::..:.....|...||
Human   257 EQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRN 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	29/55 (53%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		9/26 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		14/72 (19%)
		Homeodomain	248..304	CDD:459649	29/55 (53%)