Protein Alignment ems and GBX1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 81/320 - (25%)
• Similarity: 110/320 - (34%)
• Gaps: 114/320 - (35%)

  Fly   238 PPPNYPKPA-MMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDI------------ 289
            |||  |:.. :::.|  .||.||..|   ||.|..:.|.  |:|.|.|.|..:
Human    33 PPP--PRSGHLLYTG--YPMFMPYRP---LVLPQALAPA--PLPAGLPPLAPLASFAGRLTNTFC 88

  Fly   290 ----KALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPN 350
                :|:|..:.....||....|........::|||        .|||||.||...|......|.
Human    89 AGLGQAVPSMVALTTALPSFAEPPDAFYGPQELAAA--------AAAAAATAARNNPEPGGRRPE 145

  Fly   351 PGMARDSY-------------------QLYPWLLSRHGRIFPH---------------------- 374
            .|:..|..                   :.:| .|...|:::..
Human   146 GGLEADELLPAREKVAEPPPPPPPHFSETFP-SLPAEGKVYSSDEEKLEASAGDPAGSEQEEEGS 209

  Fly   375 --------------RFPGSFLVP------------------------PFRKPKRIRTAFSPSQLL 401
                          ..||:.|.|                        |..|.:|.||||:..|||
Human   210 GGDSEDDGFLDSSAGGPGALLGPKPKLKGSLGTGAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLL 274

  Fly   402 KLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQRN 461
            :||..|...:|:...||..:|..|.|||.|||:||||||.|.||::..:.....|...||
Human   275 ELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRN 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	29/55 (53%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		19/137 (14%)
		Homeodomain	262..318	CDD:459649	29/55 (53%)