Protein Alignment ems and Tlx2

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_033418.1
• Gene: Tlx2 / 21909
• MGIID: 1350935
• Length: 284
• Species: Mus musculus
• Alignment Length: 305
• Identity: 83/305 - (27%)
• Similarity: 111/305 - (36%)
• Gaps: 124/305 - (40%)

  Fly   188 MEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGG 252
            ||.|...|..:  ||..|.|.....         ::|.|          :||          .||
Mouse     1 MEPAVLAAHHL--PHHEPISFGIDQ---------ILSGP----------EPP----------GGG 34

  Fly   253 AGPMM-----------------MPGMPPAGLVRPFP----MGPGGP-PMPQGQPGLPDIKALPPY 295
            .||..                 ..|..|||.:...|    :||||. .:|..:| ||    :||.
Mouse    35 LGPGQSGQSHGESAAFSSGFHGASGYAPAGSLASLPRGSGVGPGGVIRVPAHRP-LP----VPPP 94

  Fly   296 INAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPA--AAAAAAAGLPPHAAQFMPNPGMARDSY 358
            ..|.|.:|                         ||:  ..|...|||
Mouse    95 SGAAPAVP-------------------------GPSGLGGAGGLAGL------------------ 116

  Fly   359 QLYPWLLSRHGRIFP--------HRFPGSFLV--------PPFRKPKRIRTAFSPSQLLKLEHAF 407
             .:||:.|  ||.|.        ..|.|:..:        ||  |.|:.||:||.||:|:||..|
Mouse   117 -TFPWMDS--GRRFAKDRLTAALSPFSGTRRIGHPYQNRTPP--KRKKPRTSFSRSQVLELERRF 176

  Fly   408 ESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEK 452
            ...:|:..|||.|||:.|.:::.|||.||||||||.:|...|:.:
Mouse   177 LRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEERE 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	30/55 (55%)
Tlx2	NP_033418.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..52		8/60 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..104		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..166		8/27 (30%)
		Homeodomain	158..214	CDD:459649	30/55 (55%)