Protein Alignment ems and Nkx2-1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001390509.1
• Gene: Nkx2-1 / 21869
• MGIID: 108067
• Length: 423
• Species: Mus musculus
• Alignment Length: 353
• Identity: 82/353 - (23%)
• Similarity: 127/353 - (35%)
• Gaps: 106/353 - (30%)

  Fly   178 KRERSPA--PPAMEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPP- 239
            :|.::.|  ||::..::     ::...:.|..|.|..|..|....:.:|..|.||........|
Mouse    12 RRAKTNARQPPSLHSSQ-----LRRTRSTPLRVHPTRSALSRRRIMSMSPKHTTPFSVSDILSPL 71

  Fly   240 -PNYPKPAMMHPGGAGPMMM----PGMPPAGLVRPFPMG-------------PGGPPMPQGQPG- 285
             .:|.|..|...|...|:..    ...|||..::...:|             .|.|.:.....|
Mouse    72 EESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGG 136

  Fly   286 -----LPDIKALPPY-------INAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAA 338
                 |.::..||||       .:.|.......:|...|.::|           :|||:.
Mouse   137 YCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRF-----------MGPASG----- 185

  Fly   339 GLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKL 403
                     |...||..         |...|.:..:..|    :|...:.|| |..||.:|:.:|
Mouse   186 ---------MNMSGMGG---------LGSLGDVSKNMAP----LPSAPRRKR-RVLFSQAQVYEL 227

  Fly   404 EHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQ---------QEDEKGGEGGSQ 459
            |..|:..:|:...||:.||..::|:.||||:||||.|.|.||..         |:|..||.||.
Mouse   228 ERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG- 291

  Fly   460 RNMHNGSGDEDDDELIDMEMDECPSDEE 487
                .|:|              ||..::
Mouse   292 ----GGAG--------------CPQQQQ 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	25/55 (45%)
Nkx2-1	NP_001390509.1	Homeodomain	213..269	CDD:459649	25/56 (45%)