Protein Alignment ems and Pitx1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_035227.1
• Gene: Pitx1 / 18740
• MGIID: 107374
• Length: 315
• Species: Mus musculus
• Alignment Length: 190
• Identity: 51/190 - (26%)
• Similarity: 77/190 - (40%)
• Gaps: 63/190 - (33%)

  Fly   289 IKALPPYINAPPELPPQHNP----HLIAAAQ----FQMAAA----------LQAGHVLGPAAAAA 335
            ::.||..:..||  ||.|:.    ||..||.    .:.:|:          .:.|...||....|
Mouse    10 LERLPEGLRPPP--PPPHDMGPSFHLARAADPREPLENSASESSDADLPDKERGGEAKGPEDGGA 72

  Fly   336 AAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPK--RIRTAFSPS 398
            .:||.          .|.|.|                           |.:|.|  |.||.|:..
Mouse    73 GSAGC----------GGGAED---------------------------PAKKKKQRRQRTHFTSQ 100

  Fly   399 QLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQEDE----KGG 454
            ||.:||..|:.|:|...:.|:.:|...||:|.:|:|||:|||.|.::.::..:    |||
Mouse   101 QLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGG 160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	25/57 (44%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		30/132 (23%)
		Homeodomain	91..147	CDD:459649	24/55 (44%)
		Interaction with PIT-1	151..280		3/10 (30%)
		OAR	277..294	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291