Protein Alignment ems and Nkx6-1

DIOPT Version :9

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 372
• Identity: 100/372 - (26%)
• Similarity: 136/372 - (36%)
• Gaps: 119/372 - (31%)

  Fly   184 APP-----AMEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYP 243
            :||     :|.:.:.|   :.|...||....|.||..|||.:   |||          .||....
Mouse    19 SPPLAALHSMAEMKTP---LYPAAYPPLPTGPPSSSSSSSSS---SSP----------SPPLGSH 67

  Fly   244 KPAMMHPGGAGPMMMPGMPPAGLVRPFPMG------------PGGPPMPQGQP------------ 284
            .|..:.|..||.:...|.||..|....|.|            ..|..:|...|
Mouse    68 NPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSAS 132

  Fly   285 ---------------------------GLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAAL 322
                                       |||...:|     :||..||
Mouse   133 ATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSL-----SPPPPPP------------------ 174

  Fly   323 QAGHVLGPAAAAAAAAGLPPHAAQFMPN------PGMARDSYQLYPWLLSRHGRI--FPHRFPGS 379
              |....|:|||.||.|..|.....:|.      ||:    .|..||   |..|:  .||:  ||
Mouse   175 --GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGV----MQSPPW---RDARLACTPHQ--GS 228

  Fly   380 FLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHK 444
            .|:....|.|..|..||..|:..||..||..:|:.|.||..||.:|.::|:||||||||||||.:
Mouse   229 ILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWR 293

  Fly   445 RMQQED----EKGGEGGSQRNMHNGSGDEDDDELIDMEMDECPSDEE 487
            :....:    :|..:..::|.......:||||: .:..:|....||:
Mouse   294 KKHAAEMATAKKKQDSETERLKGTSENEEDDDD-YNKPLDPNSDDEK 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	28/51 (55%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		27/113 (24%)
		Repressor domain. /evidence=ECO:0000250	102..269		47/200 (24%)
		Homeobox	240..293	CDD:278475	28/52 (54%)
		DUF3381	<291..345	CDD:288694	10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		9/46 (20%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		8/34 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810