DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ems and Msx2

DIOPT Version :9

Sequence 1:NP_731868.1 Gene:ems / 41697 FlyBaseID:FBgn0000576 Length:494 Species:Drosophila melanogaster
Sequence 2:NP_038629.2 Gene:Msx2 / 17702 MGIID:97169 Length:267 Species:Mus musculus


Alignment Length:216 Identity:70/216 - (32%)
Similarity:93/216 - (43%) Gaps:57/216 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 PAGLVRPFPMGPGGPPMPQGQ--------PGLP-DIKAL-----PPYINAPPELPPQHNPHLIAA 313
            ||.|..|.| ||||   .:|.        ..|| .::||     ||  ...|.:||.        
Mouse    18 PAVLAGPGP-GPGG---AEGSAEERRVKVSSLPFSVEALMSDKKPP--KESPAVPPD-------- 68

  Fly   314 AQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPG-----------MARDSYQLYPWLLSR 367
                   ...||.||.|..       ||.|..:...:||           .:.:|....|| :..
Mouse    69 -------CASAGAVLRPLL-------LPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPW-IQE 118

  Fly   368 HGRIFP---HRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSE 429
            .||..|   |..|.:..:...:..::.||.|:.||||.||..|...||:..|||...:.:|||:|
Mouse   119 PGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTE 183

  Fly   430 TQVKVWFQNRRTKHKRMQQED 450
            ||||:||||||.|.||:|:.:
Mouse   184 TQVKIWFQNRRAKAKRLQEAE 204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
emsNP_731868.1 Homeobox 392..444 CDD:278475 30/51 (59%)
Msx2NP_038629.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42 10/27 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..132 7/28 (25%)
Homeobox 145..198 CDD:306543 30/52 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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