Protein Alignment ems and DLX2

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 78/282 - (27%)
• Similarity: 103/282 - (36%)
• Gaps: 102/282 - (36%)

  Fly   222 LISSPHAT-----PPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPP--- 278
            |::..|:|     ....|.||||..         |||                   ||||..
Human     8 LVADMHSTQIAASSTYHQHQQPPSG---------GGA-------------------GPGGNSSSS 44

  Fly   279 ----MPQGQPGLPDIKALPP--YINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAA 337
                .||..|.||...|...  |.|       |.:|                        |....
Human    45 SSLHKPQESPTLPVSTATDSSYYTN-------QQHP------------------------AGGGG 78

  Fly   338 AGLPPHA--------AQFMPN-PGMARDSYQL-YPWLLSRHGRIFPHRFPGS------FLVPPFR 386
            .|..|:|        |..:.| |..|:.||.| |....:.:........|.:      .|.|..|
Human    79 GGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIR 143

  Fly   387 ----KPKRI---RTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHK 444
                |||::   ||.:|..||..|:..|:..||:...||..||.:|.|::||||:||||||:|.|
Human   144 IVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 208

  Fly   445 RMQQEDEKGGEGGSQRNMHNGS 466
            :|.    |.||..|::  |.|:
Human   209 KMW----KSGEIPSEQ--HPGA 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/58 (47%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		23/123 (19%)
		DLL_N	51..132	CDD:463567	22/111 (20%)
		Homeodomain	153..209	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328