DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ems and DLX2

DIOPT Version :9

Sequence 1:	NP_731868.1	Gene:	ems / 41697	FlyBaseID:	FBgn0000576	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	282	Identity:	78/282 - (27%)
Similarity:	103/282 - (36%)	Gaps:	102/282 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LISSPHAT-----PPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPP--- 278
            |::..|:|     ....|.||||..         |||                   ||||..
Human     8 LVADMHSTQIAASSTYHQHQQPPSG---------GGA-------------------GPGGNSSSS 44

  Fly   279 ----MPQGQPGLPDIKALPP--YINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAA 337
                .||..|.||...|...  |.|       |.:|                        |....
Human    45 SSLHKPQESPTLPVSTATDSSYYTN-------QQHP------------------------AGGGG 78

  Fly   338 AGLPPHA--------AQFMPN-PGMARDSYQL-YPWLLSRHGRIFPHRFPGS------FLVPPFR 386
            .|..|:|        |..:.| |..|:.||.| |....:.:........|.:      .|.|..|
Human    79 GGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIR 143

  Fly   387 ----KPKRI---RTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHK 444
                |||::   ||.:|..||..|:..|:..||:...||..||.:|.|::||||:||||||:|.|
Human   144 IVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 208

  Fly   445 RMQQEDEKGGEGGSQRNMHNGS 466
            :|.    |.||..|::  |.|:
Human   209 KMW----KSGEIPSEQ--HPGA 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	26/51 (51%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		23/123 (19%)
		DLL_N	51..132	CDD:289198	22/111 (20%)
		Homeobox	155..208	CDD:278475	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810