Protein Alignment ems and GSX2

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_573574.2
• Gene: GSX2 / 170825
• HGNCID: 24959
• Length: 304
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 97/316 - (30%)
• Similarity: 121/316 - (38%)
• Gaps: 120/316 - (37%)

  Fly   237 QPPPNYPKPAMMHPGGAGPMMMP-GMPPAGLVRPFPMGPGGPPMPQGQPG--------------- 285
            :|.|:.|:|   |||  ....:| ||||     |..|...||..|..:.|
Human    17 RPAPSLPEP---HPG--PDFFIPLGMPP-----PLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHS 71

  Fly   286 ------------------------------LPDIKALPPYINAPPEL--------------PPQH 306
                                          ||.:|.  .:.:||.:.              ||||
Human    72 SRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKG--QFSSAPGDAQFCPRVNHAHHHHHPPQH 134

  Fly   307 NPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRI 371
            :.|.....|...|||..|.   ..|||||||.|.|.|.|     |.....:|.:..
Human   135 HHHHHQPQQPGSAAAAAAA---AAAAAAAAALGHPQHHA-----PVCTATTYNVAD--------- 182

  Fly   372 FPHRF-------PGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSE 429
             |.||       ..:..||   ..||:||||:.:|||:||..|.||.|:....|..:|..|||||
Human   183 -PRRFHCLTMGGSDASQVP---NGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSE 243

  Fly   430 TQVKVWFQNRRTKHKRMQQEDEKGGEG-GSQRNMHNG----------SGDEDDDEL 474
            .|||:||||||.|||:         || |:|||.|.|          :..||:|.|
Human   244 KQVKIWFQNRRVKHKK---------EGKGTQRNSHAGCKCVGSQVHYARSEDEDSL 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	33/55 (60%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..151		9/34 (26%)
		Homeodomain	203..259	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..304		4/8 (50%)