Protein Alignment ems and Hoxb13

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_032293.1
• Gene: Hoxb13 / 15408
• MGIID: 107730
• Length: 286
• Species: Mus musculus
• Alignment Length: 263
• Identity: 72/263 - (27%)
• Similarity: 102/263 - (38%)
• Gaps: 57/263 - (21%)

  Fly   224 SSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMM----PGMPPAGLVRPFPMGPGGPPMPQGQP 284
            |||.|:.|......|..||....:  ||.|.|...    ||:|......|.|.|..|......:.
Mouse    31 SSPLASHPAAPTLMPTVNYAPLDL--PGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRV 93

  Fly   285 GLPDIK------ALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPH 343
            ....:|      ||..|   |.|.|.....:.....:|    |...|:   |......|:.|...
Mouse    94 SRSSLKPCAQTAALATY---PSETPAPGEEYPSRPTEF----AFYPGY---PGPYQPMASYLDVS 148

  Fly   344 AAQFMPNPGMAR-------DSYQLYPWLLSR--------HGRIFPHRFPGSFL-----------V 382
            ..|.:..||..|       ||||  ||.|:.        .|...|   ||.|.           .
Mouse   149 VVQTLGAPGEPRHDSLLPVDSYQ--PWALAGGWNSQMCCQGEQNP---PGPFWKAAFAEPSVQHP 208

  Fly   383 PP----FRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKH 443
            ||    ||:.::.|..:|..||.:||..:.:|:::...:|:.::...:|||.|:.:||||||.|.
Mouse   209 PPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKE 273

  Fly   444 KRM 446
            |::
Mouse   274 KKV 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	19/55 (35%)
Hoxb13	NP_032293.1	HoxA13_N	12..124	CDD:463521	26/97 (27%)
		Homeodomain	219..275	CDD:459649	19/55 (35%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	219..248		7/28 (25%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q92826	260..275		8/14 (57%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	272..275		1/2 (50%)