Protein Alignment ems and Hhex

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 289
• Identity: 81/289 - (28%)
• Similarity: 111/289 - (38%)
• Gaps: 84/289 - (29%)

  Fly   249 HPG-GAGPMMMPGMP---PAGLVRPFPMGP--------GGPPMPQGQPGLPD--------IKALP 293
            ||| .|.|.:  |:|   |..|::|....|        .||..|...|.||.        :.:..
Mouse     5 HPGPAAAPAV--GVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYR 67

  Fly   294 PYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSY 358
            ..:..|..:.|..:.|                    ||||.|||.|.........|.|....|
Mouse    68 TPVYEPTPVHPAFSHH--------------------PAAALAAAYGPSGFGGPLYPFPRTVND-- 110

  Fly   359 QLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQ 423
              |...|.||..:........||..|..|.|..:..||..|.::||..||:.:|:...|||.||:
Mouse   111 --YTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAK 173

  Fly   424 NLNLSETQVKVWFQNRRTKHKRMQQED----------------EKGGEGGSQRNMHNGSG----- 467
            .|.|||.|||.||||||.|.:|::||:                |:|.:..|::|  .|:.
Mouse   174 MLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQGQDLPSEQN--KGASLDRSQ 236

  Fly   468 ---------------DEDDDELIDMEMDE 481
                           .||.|:.:|:|.|:
Mouse   237 CSPSPASQEDPDSEISEDSDQEVDIEGDK 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	28/55 (51%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		38/158 (24%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		42/130 (32%)
		Homeodomain	143..195	CDD:459649	27/51 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		14/73 (19%)