Protein Alignment ems and NKX2-6

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 69/267 - (25%)
• Similarity: 97/267 - (36%)
• Gaps: 101/267 - (37%)

  Fly   208 VSPQSSQPSSSPTLL-----ISSPHATPPQQQQQQPPPNY--------PKPAMMH--PGGAGPMM 257
            :||.:|.|.|...:|     .|.| |..|..:.::.|.|:        |:.:.:|  .||.|...
Human     3 LSPVTSTPFSVKDILRLERERSCP-AASPHPRVRKSPENFQYLRMDAEPRGSEVHNAGGGGGDRK 66

  Fly   258 MPGMPPAGLVRPFPMGPGGP----------PMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIA 312
            :.|..|          ||||          .|.:.||||          ||
Human    67 LDGSEP----------PGGPCEAVLEMDAERMGEPQPGL----------NA-------------- 97

  Fly   313 AAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFP 377
                              |:.......:|....      |.:.||.        |.||...
Human    98 ------------------ASPLGGGTRVPERGV------GNSGDSV--------RGGRSEQ---- 126

  Fly   378 GSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTK 442
                 |..|:.::.|..||.:|:|.||..|:..:|:...||:.||..|.|:.||||:||||||.|
Human   127 -----PKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYK 186

  Fly   443 HKRMQQE 449
            .||.:|:
Human   187 CKRQRQD 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	26/55 (47%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		34/188 (18%)
		Homeodomain	133..189	CDD:459649	26/55 (47%)