DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ems and Dlx2

DIOPT Version :9

Sequence 1:	NP_731868.1	Gene:	ems / 41697	FlyBaseID:	FBgn0000576	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_034184.1	Gene:	Dlx2 / 13392	MGIID:	94902	Length:	332	Species:	Mus musculus

Alignment Length:	264	Identity:	74/264 - (28%)
Similarity:	97/264 - (36%)	Gaps:	87/264 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LISSPHAT-----PPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPP--- 278
            |::..|:|     ....|.|||           |.|||                 .||||..
Mouse     8 LVADMHSTQITASSTYHQHQQP-----------PSGAG-----------------AGPGGNSNSS 44

  Fly   279 -------MPQGQPGLPDIKALPP--YINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAA 334
                   .||..|.||...|...  |.|       |.:|               ||...|.|:..
Mouse    45 SSNSSLHKPQESPTLPVSTATDSSYYTN-------QQHP---------------AGGGGGGASPY 87

  Fly   335 AAAAGLPPHAAQFMPNPGMARDSYQL-YPWLLSRHGRIFPHRFPGS---------FLVPPFR--- 386
            |.......||:........|:.||.| |....:.:.   |:....|         .|.|..|
Mouse    88 AHMGSYQYHASGLNNVSYSAKSSYDLGYTAAYTSYA---PYGTSSSPVNNEPDKEDLEPEIRIVN 149

  Fly   387 -KPKRI---RTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQ 447
             |||::   ||.:|..||..|:..|:..||:...||..||.:|.|::||||:||||||:|.|:|.
Mouse   150 GKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMW 214

  Fly   448 QEDE 451
            :..|
Mouse   215 KSGE 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	26/51 (51%)
Dlx2	NP_034184.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..83		24/113 (21%)
		DLL_N	54..135	CDD:289198	23/105 (22%)
		Homeobox	158..211	CDD:278475	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..272		74/264 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810