DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ems and Cdx4

DIOPT Version :9

Sequence 1:	NP_731868.1	Gene:	ems / 41697	FlyBaseID:	FBgn0000576	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_031700.1	Gene:	Cdx4 / 12592	MGIID:	88362	Length:	282	Species:	Mus musculus

Alignment Length:	283	Identity:	70/283 - (24%)
Similarity:	103/283 - (36%)	Gaps:	83/283 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMMHPGG--AGPMMMPGMPPAGLVRPFPMGP 274
            |..|:|:.|.....||..           .||..:.|.|.|  .|....|..||......:|
Mouse    37 SPLPASNFTAAPVYPHYV-----------GYPHMSNMDPHGPSLGAWSSPYSPPREDWSTYP--- 87

  Fly   275 GGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAG 339
             |||...|...:.|:.:  |...:|..                        ..|||.:.|:....
Mouse    88 -GPPSTMGTVPMNDMTS--PVFGSPDY------------------------STLGPTSGASNGGS 125

  Fly   340 LPPHAAQFM----------PNPGMARDSYQLYPWL---LSRHGRIFPHRFPGSFLVPPFRKPKRI 391
            ||..|::.:          .:|..:|.|  .|.|:   :...|:.              |..::.
Mouse   126 LPDAASESLVSLDSGTSGATSPSRSRHS--PYAWMRKTVQVTGKT--------------RTKEKY 174

  Fly   392 RTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRM-----QQEDE 451
            |..::..|.|:||..|..|:|:....:..||.||.|||.|||:||||||.|.::|     .|.:.
Mouse   175 RVVYTDHQRLELEKEFHCNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFEN 239

  Fly   452 KGGEGGSQRNMHNGSGDEDDDEL 474
            .||      ::.:.||.....||
Mouse   240 TGG------SVQSDSGSISPGEL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	25/51 (49%)
Cdx4	NP_031700.1	Caudal_act	13..160	CDD:309740	35/165 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..156		13/85 (15%)
		Homeobox	175..227	CDD:306543	25/51 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810