DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ems and Cdx2

DIOPT Version :9

Sequence 1:	NP_731868.1	Gene:	ems / 41697	FlyBaseID:	FBgn0000576	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_031699.2	Gene:	Cdx2 / 12591	MGIID:	88361	Length:	311	Species:	Mus musculus

Alignment Length:	276	Identity:	70/276 - (25%)
Similarity:	103/276 - (37%)	Gaps:	81/276 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 PPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKP--AMMH-------PGGAGPMMMP 259
            |...||| ...|......:.::..||......|.|.|::|..  |.:.       ||||.
Mouse    28 PQNFVSP-PQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAA----- 86

  Fly   260 GMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPEL----PPQHNPHLIAAAQFQMAA 320
                |.......:..|.|....|             .::|.|.    .|.|:||..||:....:.
Mouse    87 ----AANAVAHGLNGGSPAAAMG-------------YSSPAEYHAHHHPHHHPHHPAASPSCASG 134

  Fly   321 ALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPF 385
            .||..: |||...||.||     |.|..|: |..|:   |..|:
Mouse   135 LLQTLN-LGPPGPAATAA-----AEQLSPS-GQRRN---LCEWM--------------------- 168

  Fly   386 RKP--------------KRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWF 436
            |||              .:.|..::..|.|:||..|..::|:....:..||..|.|||.|||:||
Mouse   169 RKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWF 233

  Fly   437 QNRRTKHKRMQQEDEK 452
            ||||.|.::::::.::
Mouse   234 QNRRAKERKIKKKQQQ 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeobox	392..444	CDD:278475	23/51 (45%)
Cdx2	NP_031699.2	Caudal_act	13..170	CDD:282574	44/195 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..151		14/40 (35%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q99626	185..215		7/29 (24%)
		Homeobox	189..241	CDD:278475	23/51 (45%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250\|UniProtKB:Q99626	227..241		10/13 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..311		1/11 (9%)
		4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269\|PubMed:16027724	281..293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900